FUNCTIONAL BRAIN IMAGING IN NORMAL AGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究假设如下：1)老化的大脑中发生了动态神经元网络属性的变化，影响了感觉和认知加工；2)这些变化可以通过脑磁图(MEG)进行量化。一般而言，尽管感觉处理发生在大脑的专用单位，但认知绑定过程会因衰老过程而以依赖时间的方式改变，从而导致感觉-运动整合的改变。主要目的如下：1)对听觉诱发丘脑皮质活动的时间重置进行成像和分析。2)探讨心理物理体感阈值与老年个体初级感觉皮层神经活动的特定模式之间是否存在相关性。3)对视觉诱发丘脑-皮质脑活动的时间重置进行成像和分析。4)分析语言知觉加工及其在衰老过程中的变化。将招募165人(每5岁年龄组15人，年龄在25-80岁之间)，并接受神经心理测试以及自发和感官诱发的脑磁图测量，以从与4个目标相关的刺激中检测重置和绑定参数。脑磁图的结果将被叠加在MRI/MRS图像上，以揭示正常衰老时感觉和认知衰退的潜在神经生物学关联。此外，将使用度量和光谱参数来定义对象之间的相似性分数，以及个人分数。个体得分可以与神经心理评估相关联。临床和认知评估将每隔两年重复一次。患者招募将包括纽约大学NIA支持的阿尔茨海默病中心的现有患者群体。该部门。精神病学还将提供特征良好、健康、认知正常的受试者。这是一项大胆的尝试，旨在刻画老化对神经网络生理学的影响，特别是与在短时间内处理输入刺激有关的影响。脑磁图和MRI/MRS的使用可以提供有关空间处理和神经元功能的信息。研究人员开发了一种普朗克式的感官处理量子方法。该议定书已经启动，招募工作仍在继续。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study hypothesizes the following: 1) Changes in dynamic neuronal network properties occur in the aging brain that affect sensory and cognitive processing and 2) these changes can be quantified by Magnetoencephalography (MEG). In general, although sensory processing occurs in dedicated units of the brain, the cognitive binding process, altered in a time-dependent manner by the aging process, will result in modifications of sensory-motor integration. The aims are the following: 1) To image and analyze the temporal reset of the auditory-evoked thalamo-cortical brain activity. 2) To investigate whether correlations exist between psychophysical somatosensory thresholds and specific patterns of neural activity in the primary sensory cortex in normal and aging individuals. 3) To image and analyze the temporal reset of visual-evoked thalamo-cortical brain activity. 4) To analyze language perception processing and its changes during aging. 165 individuals (in groups of 15 per 5-year age categories from 25-80) will be recruited and subjected to neuropsychological testing and spontaneous and sensory-evoked MEG measurements to detect reset and binding parameters from stimuli relating to the 4 aims. MEG findings will be overlaid on MRI/MRS images to reveal underlying neurobiologic correlates of sensory and cognitive decline in normal aging. In addition, metric and spectral parameters will be used to define similarity scores between subjects, as well as individual scores. The individual scores can be correlated with neuropsychologic assessments. The clinical and cognitive assessments will be repeated at 2-year intervals. Patient recruitment will include an existing population of patients followed by the NIA-supported Alzheimer's Disease Center at NYU. The Dept. of Psychiatry will also provide well-characterized, healthy, cognitively normal subjects. This is a bold attempt to characterize the effects of aging on neuronal network physiology, particularly as it relates to processing input stimuli in short bursts of time. The use of MEG and MRI/MRS allows for information about spatial processing and neuronal function. A Planckian quantal approach to sensory processing was developed by the investigators. This protocol has been initiated and recruitment continues.