PHARMACOKINETICS AND METABOLISM OF ANTIEPILEPTIC DRUGS IN ELDERLY PATIENTS

老年患者抗癫痫药物的药代动力学和代谢

• 批准号: 7605957
• 负责人: JAMES C. CLOYD
• 金额: $ 1.83万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605957
• 关键词: Adult; Antiepileptic Agents; Blood specimen; Carbamazepine; Collection; Computer Retrieval of Information on Scientific Projects Database; Dose; Drug Formulations; Drug Kinetics; Elderly; Exhibits; Female; Funding; Goals; Grant; Institution; Intravenous; Kinetics; Label; Metabolism; Oral; Patients; Pharmaceutical Preparations; Phenytoin; Radioactive; Research; Research Personnel; Resources; Source; Time; Treatment Protocols; United States National Institutes of Health; Urine; male; older patient

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to investigate the effect of advanced age on antiepileptic drug (AED) pharmacokinetics and metabolism. Selected elderly and adult male and female ambulatory patients taking phenytoin (PHT) or carbamazepine (CBZ) for any reason as monotherapy or with other non-interfering medications including other non-interfering AEDs will be evaluated. The patients will receive a portion of their oral dose of CBZ or PHT in a stable-labeled formulation given intravenously as 100 mg over 10 minutes (one time only). Stable-labeled CBZ and PHT are NOT radioactive and exhibit the same kinetics and metabolism as unlabeled CBZ or PHT. Blood samples and urine collections will be analyzed. In the CBZ De-Induction Study, a sub-study of the CBZ Project, subjects receive the intravenous formulation at four time points over three months while being taken off their CBZ regimen and switched to another antiepileptic drug (AED).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的目标是研究高级年龄对抗癫痫药（AED）药代动力学和代谢的影响。出于任何原因作为单一疗法或其他非互助药物（包括其他非交换AED），选择了服用苯妥英钠（PHT）或卡马西平（CBZ）的老年人和成年男性和女性门诊患者（CBZ）。患者将在10分钟内静脉注射100毫克的稳定标记配方中接受口服剂量的CBZ或PHT的一部分（仅一次）。稳定标记的CBZ和PHT不是放射性的，并且表现出与未标记的CBZ或PHT相同的动力学和代谢。将分析血液样本和尿液收集。 在CBZ De-Enctuction研究（CBZ项目的一个子研究）中，受试者在三个月内四个时间点接受静脉配方，同时将其从其CBZ方案中取出，并改用另一种抗癫痫药（AED）。