ASSESSMENT OF ANABOLIC AGENTS AND EXERCISE IN BURNED CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 背景： 严重烧伤的儿童在烧伤后长达一年的时间里对其愈合身体的能量需求增加。在这种高度新陈代谢状态下，它们会浪费脂肪和肌肉组织，并停止产生新骨。这可能会削弱他们童年的正常成长，使他们处于虚弱的状态，并阻止他们适当康复和重新融入社会。 假设： 使用有组织的运动训练计划和使用合成代谢药物将减少烧伤后的高代谢状态，并加快康复。 具体目标和程序(摘要)： 烧伤后第一年，儿童烧伤后仍处于高代谢状态，导致肌肉萎缩、虚弱、骨质流失、生长减慢、抵抗感染的能力下降，并增加了疤痕。 我们假设，通过不同的基本机制，这些分解代谢-高代谢反应可能会通过治疗性使用 O锻炼计划 O奥克斯多隆 O普萘洛尔 O-酮康唑 实验设计(摘要)： 患者将在第一次手术后5天开始进行各种锻炼和药物治疗。患者将在特定的时间间隔通过各种测试和测量(烧伤后6、9、12、18、24个月出院)进行评估。在研究结束时，将对这两组人进行比较。 意义(摘要)： 这项研究将对改善严重烧伤后的治疗具有重要意义。它将提供可能导致改进临床护理方法的信息，从而改善和加速康复进程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Children with major burn injuries have increased energy needs for their healing bodies for up to one year post burn. During this hypermetabolic state they waste fat and muscle tissue and stop producing new bone. This can diminish their normal growth of childhood, leave them in a weakened state and prevent them from proper rehabilitation and reintegration back into society. Hypothesis: The use of a structured exercise training program and the use of anabolic drugs will decrease the hypermetabolic state following burn injury and quicken rehabilitation. Specific Aims and Procedures (summary): " A hypermetabolic state continues in burned children through the first year post burn causing muscle wasting, weakness, bone loss, decreased growth, decreased ability to fight infection, and increased scarring. " We hypothesize that by separate basic mechanisms, these catabolic-hypermetabolic responses may be ameliorated by therapeutic use of o An exercise program o Oxandrolone o Propranolol o Ketoconazole Experimental Design (summary): Patients will be various groups of exercise and drugs beginning at 5 days after the first operation. Patients will be assessed at specific time intervals with a variety of tests and measurements (discharge, 6, 9, 12, 18, 24 months post burn). At the end of the study the groups will be compared to each other. Significance (summary): This study will have significant implications to improve treatment following a severe burn injury. It will provide information that may lead to improved methods of clinical care that will improve and hasten the recovery process.