SERUM BILE ACID LEVEL IN PREGNANT WOMEN WITH AND WITHOUT HIV INFECTION

感染和未感染 HIV 的孕妇的血清胆汁酸水平

• 批准号: 7605096
• 负责人: ADRIANA WEINBERG
• 金额: $ 12.46万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605096
• 关键词: Affect; Anti-Retroviral Agents; Bile Acids; Biochemical; Birth; Blood Vessels; Characteristics; Cholestasis; Clinical; Computer Retrieval of Information on Scientific Projects Database; Condition; Discipline of obstetrics; Elevation; Funding; Grant; Hepatitis C; Infection; Institution; Liver diseases; Patients; Pharmaceutical Preparations; Placental Insufficiency; Pregnancy; Pregnancy Trimesters; Pregnant Women; Research; Research Personnel; Resources; Retrospective Studies; Risk; Serum; Source; Umbilical Cord Blood; United States National Institutes of Health; Woman; fetal; neonate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Serum bile acid elevations during pregnancy are associated with obstetric cholestasis (OC), which carries significant risks of fetal demise and other complications. These are a consequence of bile acid-induced vascular placental insufficiency. OC is more common in patients with underlying liver disease (hepatitis C infection). HIV-infected women are subject to heptatotoxic agents that might increase the risk of OC. To determine if HIV-infected women have increased serum bile acid levels during pregnancy, we will compare serum bile acid levels during the 2nd and 3rd trimesters of pregnancy and in the cord blood of 40 HIV-infected, 10 Hep C-infected, and 10 uninfected pregnant women. We will identify associations between serum bile acid levels and birth conditions of the neonate. We will determine if antiretroviral medication affects bile acid levels by comparing the decrease between last month of pregnancy and post-partum in HIV-infected pregnant women who continue on therapy vs. other subjects. We will also conduct a retrospective study of OC at UCHSC to identify potential similarities between the clinical and biochemical findings associated with bile acid levels in HIV-infected pregnant women and the clinical, biochemical, and epidemiological characteristics of OC in normal pregnancy.

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 妊娠期间血清胆汁酸升高与产科胆汁淤积症（OC）相关，后者具有显著的胎儿死亡和其他并发症风险。这些是胆汁酸诱导的血管性胎盘功能不全的结果。OC在有基础肝病（丙型肝炎感染）的患者中更常见。感染艾滋病毒的妇女易受可能增加OC风险的肝毒性剂的影响。为了确定HIV感染的妇女是否在怀孕期间血清胆汁酸水平升高，我们将比较妊娠第2和第3个三个月期间以及40名HIV感染者、10名丙肝感染者和10名未感染孕妇的脐带血中的血清胆汁酸水平。我们将确定血清胆汁酸水平和新生儿出生条件之间的关联。我们将通过比较继续接受治疗的HIV感染孕妇与其他受试者在妊娠最后一个月和产后之间的下降情况，确定抗逆转录病毒药物是否影响胆汁酸水平。我们还将在UCHSC对OC进行回顾性研究，以确定与HIV感染孕妇胆汁酸水平相关的临床和生化结果与正常妊娠OC的临床、生化和流行病学特征之间的潜在相似性。