DETERMINE TIME TO DEVELOPMENT OF AIDS DEFINING COMPLICATIONS & INFECTIONS

确定艾滋病定义并发症的发展时间

• 批准号: 7605165
• 负责人: THOMAS C MERIGAN
• 金额: $ 2.09万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605165
• 关键词: AIDS clinical trial group; Adherence; Anti-Retroviral Agents; Azithromycin; Bacterial Infections; CD4 Lymphocyte Count; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Cognitive; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Deterioration; Development; Event; Funding; Grant; HIV; Highly Active Antiretroviral Therapy; Hip region structure; Immunologics; Impaired cognition; Infection; Institution; Myocardial Infarction; Opportunistic Infections; Parents; Patients; Pharmaceutical Preparations; Placebos; Plasma; Procedures; RNA; Rate; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Stroke; Time; Triglycerides; United States National Institutes of Health; Viral; cohort; follow-up; immunosuppressed; interest; mortality; sudden cardiac death

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Determine the overall rates of and risk factors for AIDS-defining complications and serious bacterial infections in subjects in the parent study, ACTG 362. Secondary 1. Determine the overall rates and risk factors (e.g. triglycerides,cholesterol, waist-to-hip ratio) for the development of cardiovascular disease in the study cohort. Cardiovascular events of interest include: myocardial infarction, coronary artery revascularization procedures, angina, sudden cardiac death, and stroke. 2. Compare the time to development of AIDS-defining complications and serious infections or cardiovascular disease in subjects who were assigned to receive Azithromycin to those who were assigned to receive placebo. 3. Evaluate the association between CD4 counts and HIV RNA levels at baseline and during follow-up and risk of opportunistic infections and other HIV-related complications. 4. Compare mortality in subjects who were assigned to receive Azithromycin to those who were assigned to receive placebo. 5. Define the risk of cognitive deterioration in a cohort of patients who have been severely immunosuppressed and recovered CD4 counts while taking Highly Active Antiretroviral Therapy (HAART). 6. Identify immunologic (CD4 counts) and virologic (plasma HIV RNA levels) markers and specific drugs (especially PIs) associated with cognitive decline. 7. Evaluate factors associated with long-term adherence to antiretroviral medications and the effect of adherence on viral suppression over time and on the development of opportunistic and serious bacterial infections and cardiovascular diseas

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 初级 确定母研究ACTG 362受试者中AIDS定义并发症和严重细菌感染的总体发生率和风险因素。 二次 1. 确定研究队列中发生心血管疾病的总体发生率和风险因素（例如甘油三酯、胆固醇、腰臀比）。关注的心血管事件包括：心肌梗死、冠状动脉血运重建术、心绞痛、心源性猝死和卒中。 2. 比较艾滋病定义的并发症的发展时间， 受试者严重感染或心血管疾病， 接受阿奇霉素治疗的患者。 3. 评估CD 4计数和HIV RNA水平之间的关联， 基线和随访期间以及机会性感染和其他 艾滋病毒相关并发症。 4. 比较接受阿奇霉素治疗和接受安慰剂治疗的受试者的死亡率。 5. 定义以下患者队列中认知恶化的风险： 严重免疫抑制，CD 4计数恢复，同时服用 高效抗逆转录病毒疗法（HAART）。 6. 确定免疫学（CD 4计数）和病毒学（血浆HIV RNA 水平）标志物和特定药物（尤其是PI） 认知能力下降 7. 评估与长期坚持抗逆转录病毒治疗相关的因素 药物治疗和依从性随时间对病毒抑制的影响， 机会性和严重细菌感染的发展， 心血管疾病