OBESITY AND KIDNEY FUNCTION: THE IMPACT OF WEIGHT LOSS ON RENAL FUNCTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has been steadily rising over the past few decades and has been associated with a variety of disease states. As obesity becomes more common, so does the spectrum of diseases associated with it. In the kidney, obesity leads to kidney enlargement and scarring. The kidneys of obese individuals function at greater than 100% of their capacity. This phenomenon is referred to as hyperfiltration. There are proposed mechanisms to explain this phenomenon, but the actual mediators of hyperfiltration have not been identified. Thus, the aim of this project is threefold: 1) to confirm the presence of hyperfiltration in obese non-diabetic individuals; 2) study the impact of weight loss following bariatric surgery on kidney function; 3) and to explore the contribution of the renin-angiotensin hormonal system to this process.