OBESITY AND KIDNEY FUNCTION: THE IMPACT OF WEIGHT LOSS ON RENAL FUNCTION

肥胖与肾功能：减肥对肾功能的影响

• 批准号: 7606066
• 负责人: HASSAN N IBRAHIM
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606066
• 关键词: Angiotensins; Body Weight decreased; Cicatrix; Computer Retrieval of Information on Scientific Projects Database; Disease; Endocrine system; Funding; Grant; Individual; Institution; Kidney; Mediator of activation protein; Obesity; Process; Renal function; Renin; Research; Research Personnel; Resources; Source; United States National Institutes of Health; bariatric surgery; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has been steadily rising over the past few decades and has been associated with a variety of disease states. As obesity becomes more common, so does the spectrum of diseases associated with it. In the kidney, obesity leads to kidney enlargement and scarring. The kidneys of obese individuals function at greater than 100% of their capacity. This phenomenon is referred to as hyperfiltration. There are proposed mechanisms to explain this phenomenon, but the actual mediators of hyperfiltration have not been identified. Thus, the aim of this project is threefold: 1) to confirm the presence of hyperfiltration in obese non-diabetic individuals; 2) study the impact of weight loss following bariatric surgery on kidney function; 3) and to explore the contribution of the renin-angiotensin hormonal system to this process.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在过去的几十年里，肥胖症一直在稳步上升，并与各种疾病状态有关。随着肥胖变得越来越普遍，与之相关的疾病也越来越多。在肾脏，肥胖导致肾脏肿大和瘢痕形成。肥胖个体的肾脏功能超过其容量的100%。这种现象被称为超滤。有人提出了解释这种现象的机制，但超滤的实际介质尚未确定。因此，本项目的目的有三个：1）证实肥胖非糖尿病个体中存在超滤; 2）研究减肥手术后体重减轻对肾功能的影响; 3）并探索肾素-血管紧张素激素系统对该过程的贡献。