OBESITY AND KIDNEY FUNCTION: THE IMPACT OF WEIGHT LOSS ON RENAL FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的几十年里，肥胖症一直在稳步上升，并与各种疾病状态有关。随着肥胖变得越来越普遍，与之相关的各种疾病也越来越多。在肾脏，肥胖会导致肾脏增大和结疤。肥胖者的肾脏功能超过100%。这种现象被称为超滤。已经提出了解释这一现象的机制，但高滤过的实际介体尚未确定。因此，该项目的目标有三个：1)证实肥胖非糖尿病患者存在高滤过；2)研究减肥手术后体重减轻对肾功能的影响；3)探讨肾素-血管紧张素激素系统在这一过程中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity has been steadily rising over the past few decades and has been associated with a variety of disease states. As obesity becomes more common, so does the spectrum of diseases associated with it. In the kidney, obesity leads to kidney enlargement and scarring. The kidneys of obese individuals function at greater than 100% of their capacity. This phenomenon is referred to as hyperfiltration. There are proposed mechanisms to explain this phenomenon, but the actual mediators of hyperfiltration have not been identified. Thus, the aim of this project is threefold: 1) to confirm the presence of hyperfiltration in obese non-diabetic individuals; 2) study the impact of weight loss following bariatric surgery on kidney function; 3) and to explore the contribution of the renin-angiotensin hormonal system to this process.