INTRAUTERINE GROWTH RETARDATION AND FETAL ADAPTIVE PROGRAMMING PILOT STUDY

宫内生长迟缓和胎儿适应性编程试点研究

• 批准号: 7606087
• 负责人: MARY PYLIPOW
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606087
• 关键词: Affect; Age-Years; Brain; Brain region; Chronic; Computer Retrieval of Information on Scientific Projects Database; Development; Fatty acid glycerol esters; Fetal Growth Retardation; Funding; Glucose; Grant; Growth; Hydrocortisone; Infant; Inflammatory; Institution; Insulin; Interleukin-6; Investigation; Leptin; Life; Memory; Metabolic; Neurosecretory Systems; Nutritional; Pattern; Pilot Projects; Research; Research Personnel; Resources; Somatomedins; Source; Stress; TNF gene; United States National Institutes of Health; Weight; cytokine; deprivation; fetal; programs; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose a pilot study of long term brain development, neuroendocrine function and cytokines in former Itrauterine Growth Restricted (IUGR) infants who and are now 7-9 years of age. The aims are (1) first identify the regions of the brain most affected by chronic intrauterine stress and nutritional deprivation leading to IUGR through this pilot study so that we subsequently perform targeted prospective investigations in the newly born (IUGR) infant during development; and (2) define growth patterns in IUGR infants (linear, weight, and velocity of catch-up) and their association with brain (memory), inflammatory (IL-6 and TNF) growth (IGF) cytokines, and neuroendocrine and metabolic (leptin/fat, insulin/glucose, and cortisol/stress) function later in life.

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