COGNITION AND IMAGING IN TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是调查成人(18-65岁)创伤性脑损伤(TBI)幸存者和健康对照组之间的认知和脑结构差异。这个项目将试图证明脑外伤后脑白质微结构的完整性可能受到损害，并且这种创伤可能与神经认知功能受损有关。我们建议使用弥散张量成像(DTI)来研究脑外伤患者的脑白质异常，这是一种以前从未被用于研究这一患者群体的磁共振成像(MRI)方法。这些发现可能会增加我们对脑损伤如何影响脑白质和认知的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the cognitive and structural brain differences between adult (ages 18-65) survivors of a Traumatic Brain Injury (TBI) and healty controls. This project will seek to demonstrate that microstructural white matter integrity may be compromised after TBI and that this trauma may be associated with impaired neurocognitive functioning. We propose to investigate white matter abnormalities in TBI patients by using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) method that has not previously been used to explore this patient population. These findings could increase our understanding of how white matter and cognition are affected by TBI.