COGNITION AND IMAGING IN TRAUMATIC BRAIN INJURY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是调查成人（18-65岁）创伤性脑损伤（TBI）幸存者和健康对照者之间的认知和结构脑差异。该项目将试图证明，脑外伤后，微结构白色物质的完整性可能会受到损害，这种创伤可能与受损的神经认知功能。我们建议使用弥散张量成像（DTI），磁共振成像（MRI）的方法，以前还没有被用来探索这一患者群体的白色物质异常调查TBI患者。这些发现可以增加我们对TBI如何影响白色物质和认知的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to investigate the cognitive and structural brain differences between adult (ages 18-65) survivors of a Traumatic Brain Injury (TBI) and healty controls. This project will seek to demonstrate that microstructural white matter integrity may be compromised after TBI and that this trauma may be associated with impaired neurocognitive functioning. We propose to investigate white matter abnormalities in TBI patients by using Diffusion Tensor Imaging (DTI), a magnetic resonance imaging (MRI) method that has not previously been used to explore this patient population. These findings could increase our understanding of how white matter and cognition are affected by TBI.