THE VENTILATORY RESPONSE TO OCCLUSION-INDUCED AROUSAL IN HEALTHY MEN AND WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的具体目的是：1)确定阻塞性唤醒是否能引起高呼吸道阻力人群(打鼾者)的呼吸不稳定，以及哪些因素与唤醒后的呼吸不稳定有关；2)确定鼾症者对阻塞性唤醒的呼吸反应是否比不打鼾者大；3)确定健康男性和女性对阻塞性唤醒的呼吸反应是否不同。研究人员假设，a)在唤醒之前具有高呼吸道阻力的个体(打鼾者)，闭塞诱导唤醒会在恢复睡眠时导致呼吸不稳定；b)打鼾者对闭塞诱导唤醒的呼吸反应将比不打鼾者更高；以及c)健康男性对闭塞诱导唤醒的呼吸反应将高于女性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this study are to 1) determine whether occlusion induced arousal can induce breathing instability in people with high airways resistance (snorers) and what factors are related to breathing instability post arousal; 2) To determine whether the ventilatory response to occlusion-induced arousal is larger in snorers than non-snorers; and 3) to determine whether the ventilatory response to occlusion induced arousal is different between healthy men and women. The researchers hypothesize that a) occlusion-induced arousal will induce breathing instability on return to sleep in individuals who have high airways resistance prior to arousal (snorers); b) the ventilatory response to occlusion-induced arousal will be higher in snorers than in non-snorers; and c) the ventilatory response to occlusion-induced arousal will be higher in healthy men than in women.