VASCULAR FUNCTIONAL ABNORMALITIES AND DIABETIC FOOT ULCERATION

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是一项队列研究，包括150名足部溃疡高危糖尿病患者、25名无风险糖尿病患者和25名健康对照受试者。本研究的主要目的是确定毛细血管和小动脉（微循环）以及大动脉（大循环）的血管功能测量值，这些测量值可以预测足部溃疡。更具体地说，将招募150名有发生足部溃疡风险的糖尿病患者，并随访长达三年。一组25名非神经病患者和一名25名健康受试者也将被随访作为对照。所有患者将在首次访视后18个月进行复查。血管反应性表明血管扩张和增加血流量的能力，将通过在参与者中采用非侵入性技术来测量。还将测量指示血管功能的生化因子。最后，将进行前臂皮肤活检，以评估血管功能受损的相关因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cohort study of 150 diabetic patients at high risk of foot ulceration, 25 diabetic patients not at risk and 25 healthy control subjects. The main purpose of the study is to identify measurement of vascular function, of both the capillaries and arterioles (microcirculation) and large arteries (macrocirculation) that can predict foot ulceration. More specifically, 150 diabetic patients at risk of developing foot ulceration will be recruited and followed for a period up to three years. One group of 25 non-neuropathic patients and one of 25 healthy subjects will also be followed up to serve as controls. All patients will be re-examined 18 months after their initial visit. The vascular reactivity, which indicates the ability of the vessel to dilate and increase the blood flow, will be measured by employing non-invasive techniques in the participants. Biochemical factors that are indicative of vascular function will also be measured. Finally, forearm skin biopsies will be performed in an effort to evaluate the factors that are involved in the impairment of the vascular function.