NON-INVASIVE IMAGING OF GI INFLAMMATION USING MICROBUBBLE CEU

使用微泡 CEU 对胃肠道炎症进行非侵入性成像

• 批准号: 7606726
• 负责人: Brian W Behm
• 金额: $ 0.09万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606726
• 关键词: Area; Blood flow; Chronic; Colonoscopy; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Diagnostic; Disease; Encapsulated; Enrollment; Funding; Grant; Image; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory disease of the intestine; Institution; Intestines; Invasive; Large Intestine; Location; Measures; Methods; Microbubbles; Patients; Publishing; Rank-Sum Tests; Research; Research Personnel; Resources; Role; Score; Severities; Source; System; Ultrasonography; United States National Institutes of Health; animal data; indexing; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory bowel disease (IBD) is a common chronic inflammatory disorder, but a noninvasive method of assessing disease location, severity, and extent is currently not available. Recently published animal data suggests that using transabdominal ultrasound enhanced with encapsulated gaseous microbubbles may provide a reliable, noninvasive means to detect and quantify areas of intestinal inflammation. This study will evaluate the role of Contrast-enhanced ultrasonography (CEU) for use as a diagnostic tool in patients with IBD. We hypothesize that the severity and extent of chronic intestinal inflammation, as quantified by CEU-derived video intensity scores, will correlate with endoscopically-derived measures of intestinal inflammation as obtained from the Crohn's Disease Endoscopic Inflammatory Index (CDEIS). A total of 40 patients will be enrolled in the study, 30 patients with IBD and 10 patients undergoing colonoscopy for other reasons. Prior to colonoscopy CEU assessment of small and large intestine will be performed to evaluate neoangiogenesis and intestinal blood flow. The correlation between the CEU-derived video intensity score and CDEIS will be assessed using Pearson's correlation coeffient. Comparing video intensity between IBD and non-IBD subjects will be performed using the Wilcoxon rank sum test, with a secondary aim of establishing preliminary estimates of the sensitivity of the microbubble scoring system.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 炎症性肠病（IBD）是一种常见的慢性炎症性疾病，但目前还没有一种评估疾病部位、严重程度和程度的非侵入性方法。 最近发表的动物数据表明，使用经腹超声增强与封装的气体微泡可以提供一个可靠的，非侵入性的手段来检测和量化肠道炎症的区域。 本研究将评价造影剂增强超声检查（CEU）作为IBD患者诊断工具的作用。 我们假设慢性肠道炎症的严重程度和程度，如通过CEU衍生的视频强度评分量化的，将与从克罗恩病内窥镜炎症指数（CDEIS）获得的内窥镜衍生的肠道炎症指标相关。 本研究共入组40例患者，30例IBD患者和10例因其他原因接受结肠镜检查的患者。 在结肠镜检查前，将进行小肠和大肠的CEU评估，以评价新血管生成和肠血流量。 将使用Pearson相关系数评估CEU导出的视频强度评分与CDEIS之间的相关性。 将使用Wilcoxon秩和检验比较IBD和非IBD受试者之间的视频强度，次要目的是建立微泡评分系统灵敏度的初步估计值。