INVESTIGATION OF BONE MINERAL DENSITY IN CHILDREN INFECTED WITH HUMAN IMMUNODEFS

感染人类免疫缺陷儿童的骨矿物质密度调查

• 批准号: 7606791
• 负责人: JoAnn M Lin
• 金额: $ 0.33万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-21 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606791
• 关键词: Age; Anti-Retroviral Agents; Biological Factors; Bone Density; CD4 Lymphocyte Count; Child; Class; Computer Retrieval of Information on Scientific Projects Database; Dual-Energy X-Ray Absorptiometry; Funding; Grant; HIV; Human; Incidence; Institution; Investigation; Lipodystrophy; Osteogenesis; Patients; Population; Prevalence; Research; Research Personnel; Resources; Severities; Source; Treatment Protocols; United States National Institutes of Health; Viral Load result

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. To determine the prevalence and severity of bone mineral density loss in HIV infected children compared to healthy, seronegative, age-matched controls as determined by QCT and DXA. 2. To evaluate the relationship of bone mineral density to certain biological factors, including viral load, CD4 counts, and specific markers of bone formation and resorption in HIV-infected children 3. To evaluate the association between class of antiretroviral treatment, including regimen and duration, to bone mineral density changes in HIV-infected children. 4. To describe the relationship between bone mineral density loss and incidence of lipodystrophy in this patient population.

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