PROTEIN METABOLISM IN NEWLY DIAGNOSED PEDIATRIC INFLAMMATORY BOWEL DISEASE

新诊断的小儿炎症性肠病的蛋白质代谢

• 批准号: 7606474
• 负责人: STEVEN J STEINER
• 金额: $ 0.27万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606474
• 关键词: Abdominal Pain; Adrenal Cortex Hormones; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Crohn' s disease; Diagnosis; Diarrhea; Disease; Enrollment; Essential Amino Acids; Funding; Gastrointestinal tract structure; Grant; Growth; Inflammatory Bowel Diseases; Institution; Isotopes; Measures; Newly Diagnosed; Outcome; Patients; Prospective Studies; Protein Biosynthesis; Proteins; Rate; Research; Research Personnel; Resources; Source; Symptoms; Testing; Time; Ulcerative Colitis; United States National Institutes of Health; Week; follow-up; gastrointestinal; metabolic abnormality assessment; protein metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is a disease of the gastrointestinal tract leading to symptoms of abdominal pain, diarrhea, and growth disturbance. Many patients with inflammatory bowel disease have alterations in growth prior to their diagnosis, and these alterations may persist despite therapy, leading to suboptimal growth outcomes. Alterations in whole body protein metabolism have been characterized in children with inflammatory bowel disease, and demonstrate increased protein breakdown and protein synthesis during active disease. The objective of this application is to characterize protein metabolism at the gastrointestinal mucosal level in children with newly diagnosed inflammatory bowel disease, and determine the contribution of gastrointestinal mucosal protein metabolism to whole body protein metabolism. We hypothesize that children with inflammatory bowel disease will have increased gastrointestinal mucosal protein synthesis compared to patients who have normal endoscopic findings. To test this hypothesis, children with suspected inflammatory bowel disease will be enrolled in a prospective study. Using stable essential amino acid isotopes, rates of whole body protein metabolism and gastrointestinal mucosal protein metabolism will be measured at the time of the patients' endoscopic examinations. In patients with newly diagnosed inflammatory bowel disease, a follow-up metabolic study will be conducted two weeks following the introduction of corticosteroid therapy to determine the effects of this therapy on whole body protein metabolism. These results will be significant because they may help allow for optimization of the treatment of children with inflammatory bowel disease, and may help these children to reach their true growth potential.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 炎症性肠病，包括克罗恩病和溃疡性结肠炎，是一种胃肠道疾病，导致腹痛、腹泻和生长障碍的症状。 许多患有炎症性肠病的患者在诊断之前就已经发生了生长变化，尽管进行了治疗，这些变化仍可能持续存在，导致次优的生长结果。 全身蛋白质代谢的改变在炎症性肠病儿童中已被表征，并证明在活动性疾病期间蛋白质分解和蛋白质合成增加。 本申请的目的是表征新诊断的炎症性肠病儿童胃肠粘膜水平的蛋白质代谢，并确定胃肠粘膜蛋白质代谢对全身蛋白质代谢的贡献。 我们假设，与内窥镜检查结果正常的患者相比，患有炎症性肠道疾病的儿童胃肠道粘膜蛋白质合成增加。 为了验证这一假设，将对疑似炎症性肠病的儿童进行前瞻性研究。 使用稳定的必需氨基酸同位素，在患者进行内窥镜检查时测量全身蛋白质代谢率和胃肠道粘膜蛋白质代谢率。 在新诊断的炎症性肠病患者中，将在引入皮质类固醇治疗后两周进行随访代谢研究，以确定该治疗对全身蛋白质代谢的影响。 这些结果将是重要的，因为它们可能有助于优化炎症性肠病儿童的治疗，并可能帮助这些儿童达到他们真正的生长潜力。