DIPYRIDAMOLE/MAGNESIUM TO IMPROVE SICKLE CELL HYDRATION
DIPYRIDAMOLE/MAGNESIUM TO IMPROVE SICKLE CELL HYDRATION
批准号:
7607766
负责人:
KAREN A KALINYAK
金额:
$0.11万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-02-15 至 2007-11-30
关键词:
AdultAdverse effectsBenefits and RisksBiotinCell SurvivalClinicalComputer Retrieval of Information on Scientific Projects DatabaseDipyridamoleDouble-Blind MethodEnd PointEnrollmentErythrocytesFunctional disorderFundingGoalsGrantHydration statusInstitutionLabelMagnesiumMeasuresOralOutcomePathway interactionsPatientsPediatricsPharmaceutical PreparationsPhaseRandomizedRandomized Clinical TrialsRecruitment ActivityResearchResearch PersonnelResourcesSample SizeSickle CellSickle Cell AnemiaSourceTechniquesUnited States National Institutes of Healthclinical effectcomparison groupimproved
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a multi-center trial recruiting both adults and pediatrics with sickle cell anemia (SCA). The overall goal of this study is to determine the benefits and risks of treating patients with SCA with oral dipyridamole, oral magnesium or a combination of both drugs. While they operate by blocking different pathways, both dipyridamole and magnesium appear to block or reduce the formation of dense erythrocytes (RBC) that drive the pathophysiology of vaso-occlusion in patients with SCA. Our proposed study will focus on the following aims and hypotheses: assessing effects on red cell hydration, assessing effects on red cell survival, determining side effects and evaluating clinical outcomes such as correlation between red cell hydration effects and the clinical course of the patients. This study consists of two parts: Part I, is a phase II randomized, double blind treatment study which primary endpoint is to measure red cell hydration and Part II is a randomized, clinical trial between group comparisons with the primary endpoint being red cell survival (biotin label technique). The sample size will consist of forty eight patients enrolled in Part I and eighteen patients will be recruited for Part II. The patients in Part II do not have to have participated in Part I.
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CLINICAL CORE
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批准号:8150169
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项目类别:
-
资助金额:$20.93万
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财政年份:2010
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负责人:KAREN A KALINYAK
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依托单位:
Dipyridamole/Magnesium to Improve Sickle Cell Hydration
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批准号:6782210
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项目类别:
-
资助金额:$18.37万
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财政年份:2003
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负责人:KAREN A KALINYAK
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依托单位:
Core--Clinical
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批准号:6782230
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项目类别:
-
资助金额:$10.0万
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财政年份:2003
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6584670
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项目类别:
-
资助金额:$22.86万
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财政年份:2002
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6667543
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项目类别:
-
资助金额:$22.86万
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财政年份:2002
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6584668
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项目类别:
-
资助金额:$22.86万
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财政年份:2002
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6667541
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项目类别:
-
资助金额:$22.86万
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财政年份:2002
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6456258
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项目类别:
-
资助金额:$22.86万
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财政年份:2001
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6456260
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项目类别:
-
资助金额:$22.86万
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财政年份:2001
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6325980
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项目类别:
-
资助金额:$19.22万
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财政年份:2000
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6325982
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项目类别:
-
资助金额:$19.22万
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财政年份:2000
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6110861
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项目类别:
-
资助金额:$19.22万
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财政年份:1999
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6110859
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项目类别:
-
资助金额:$19.22万
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财政年份:1999
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负责人:KAREN A KALINYAK
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依托单位:
MANAGEMENT OF SICKLE CELL VASO-0CCLUSIVE EPISODES
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批准号:6273294
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项目类别:
-
资助金额:$19.24万
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财政年份:1998
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负责人:KAREN A KALINYAK
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依托单位:
CORE--PEDIATRIC SICKLE CELL PROGRAM
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批准号:6273296
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项目类别:
-
资助金额:$19.24万
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财政年份:1998
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负责人:KAREN A KALINYAK
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依托单位:
Dipyridamole/Magnesium to Improve Sickle Cell Hydration
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批准号:7575343
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项目类别:
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资助金额:$65.5万
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财政年份:--
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负责人:KAREN A KALINYAK
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依托单位:
Core--Clinical
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批准号:7575348
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项目类别:
-
资助金额:$23.71万
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财政年份:--
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负责人:KAREN A KALINYAK
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依托单位:
OXYGENATION AND HEMOGLOBIN SATURATION DURING SLEEP IN SICKLE CELL DISEASE
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批准号:4695159
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:KAREN A KALINYAK
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依托单位:
CLINICAL CORE
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批准号:8263405
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项目类别:
-
资助金额:$21.2万
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财政年份:--
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负责人:KAREN A KALINYAK
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依托单位:
海外基金