ACTION FOR HEALTH IN DIABETES (LOOK AHEAD)

糖尿病健康行动（展望未来）

• 批准号: 7607452
• 负责人: FREDERICK L BRANCATI
• 金额: $ 1.1万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607452
• 关键词: Adult; Affect; Age-Years; Body Weight decreased; Body mass index; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Condition; Diabetes Mellitus; Disease; Electrocardiogram; Energy Intake; Event; Exercise; Exercise stress test; Funding; Grant; Health; Incidence; Institution; Intervention; Long-Term Effects; Mediating; Metabolic; Morbidity - disease rate; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Participant; Physical activity; Protocols documentation; Randomized Controlled Clinical Trials; Recruitment Activity; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Stroke; United States; United States National Institutes of Health; Upper arm; base; cost effectiveness; design; diabetes education; fitness; follow-up; intervention program; mortality; obesity risk; programs; response; volunteer; weight loss intervention

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overweight and obesity are major health problems in the United States, affecting more than 50% of adults, with 22.5% classified as obese (body mass index > 30 kg/m2). Nowhere is the long-term risk of obesity more manifest than in its effect on Type 2 diabetes. Similarly, CVD is associated with obesity, mediated in part by the two- to four-fold increased risk for CVD associated with Type 2 diabetes. Although short-term weight loss ameliorates obesity-related metabolic abnormalities and CVD risk factors, few, if any, studies have examined the long-term consequences of intentional weight loss in overweight or obese populations. This study will focus on one of the diseases most affected by overweight and obesity, Type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. The specific aim of Look AHEAD (Action for Health in Diabetes) is to examine, in overweight volunteers with Type 2 diabetes the long-term effects of an intensive weight loss intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. This program is compared to a control condition involving a program of diabetes education and support. The primary basis for the comparison is the incidence of serious cardiovascular events. Other outcomes, including CVD risk factors, diabetes related metabolic factors and complications, and the cost-effectiveness of the intensive intervention are also studied. Approximately 5,000 volunteers with Type 2 diabetes who are 45-75 years of age and overweight or obese (body mass index > 25 kg/m2) will be recruited The primary outcome is the aggregate occurrence of severe CVD events including fatal and non-fatal myocardial infarctions and strokes and CVD deaths over a planned follow-up period of up to 11.5 years. The study is a two-armed randomized, controlled clinical trial. With 5,000 participants, the study has 90% power to detect an 18% difference in major CVD events between the two intervention groups. Specific to this GCRC application, the study will also examine mechanisms through which weight loss and physical activity may influence health. The GCRC will be used to perform exercise testing to evaluate cardiovascular endurance fitness and exercise ECG responses. The Exercise Core Lab was utilized for this protocol.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 超重和肥胖是美国的主要健康问题，影响了50％以上的成年人，其中22.5％归类为肥胖（体重指数> 30 kg/m2）。肥胖症的长期风险没有比对2型糖尿病的影响更明显的地方。同样，CVD与肥胖有关，部分由与2型糖尿病相关的CVD风险增加了两到四倍。尽管短期体重减轻可以改善与肥胖相关的代谢异常和CVD危险因素，但很少（如果有的话）研究了超重或肥胖人群中故意体重减轻的长期后果。这项研究将集中于受超重和肥胖症，2型糖尿病影响最大的疾病之一，以及导致发病率最高和死亡率，心血管疾病的结果。展望未来的具体目的（糖尿病的健康作用）是在患有2型糖尿病的超重志愿者中检查强化减肥干预计划的长期影响，旨在通过减少热量摄入和增加体育活动来实现和维持体重减轻。 将该计划与涉及糖尿病教育和支持计划的控制状况进行比较。 比较的主要基础是严重心血管事件的发生率。 还研究了其他结果，包括CVD危险因素，相关的代谢因素和并发症以及强化干预的成本效益。大约5,000名2型糖尿病的志愿者年龄45-75岁，超重或肥胖（体重指数> 25 kg/m2）将被招募。主要结果是发生严重的CVD事件，包括致命的和非致命的心肌梗死和cvd死亡，超过了11.5年以后，以加强了11.5年的时间。该研究是一项两臂随机，对照临床试验。 该研究有5,000名参与者，具有90％的功率，可检测两个干预组之间的主要CVD事件差异18％。该研究特定于该GCRC应用，还将研究体重减轻和体育锻炼可能影响健康的机制。 GCRC将用于进行运动测试，以评估心血管耐力健康和运动心电图的反应。 运动核心实验室用于此协议。