EFFECT OF AORTIC IMPEDANCE ON MYOCARDIAL RELAXATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 (from CRISP网站） 左心室收缩功能正常或接近正常的充血性心力衰竭称为舒张性心力衰竭。据申请方称，认为1995年至少50%的65岁以上心力衰竭住院患者（超过350，000例患者）患有原发性舒张性心力衰竭。与舒张性心力衰竭相关的再住院率和费用与收缩性心力衰竭相当，尽管死亡率较低。尽管它的流行，舒张功能衰竭的生理学知之甚少，最佳的诊断策略尚未确定，并没有治疗已被证明可以降低疾病的死亡率。在这项研究中，65岁以上的高血压患者和年龄匹配的对照组将使用无创测量动脉硬度和心肌松弛进行研究。将测试各种血管扩张剂对这些结局的影响，以确定对动脉僵硬度的不同药理学作用是否会导致对心肌舒张的不同影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (from CRISP website) Congestive heart failure in the presence of normal or near normal left ventricular systolic function is referred to as diastolic heart failure. According to the applicant, it is thought that at least 50% of patients older than 65 years hospitalized with heart failure in 1995 (over 350,000 patients), had primary diastolic heart failure. Rates of re-hospitalization and costs associated with diastolic heart failure are equivalent to those of systolic heart failure, although mortality is lower. Despite its prevalence, the physiology of diastolic failure is poorly understood, the optimal diagnostic strategy has yet to be defined, and no therapy has been shown to lower the mortality of the disease. In this research study hypertensive patients over age 65 years and age-matched controls will be studied using non- invasive measurements of arterial stiffness and myocardial relaxation. The impact of various vasodilators on these outcomes will be tested in order to determine whether disparate pharmacological effects on arterial stiffness lead to different effects on myocardial relaxation.