PREDICTOR OF ADVANCED SUB-CLINICAL ATHEROSCLEROSIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多种危险因素导致动脉粥样硬化的发展。国家胆固醇教育计划提供了基于心脏病风险评分（FRS）的冠心病（CAD）预防、诊断和管理指南，FRS是一种为主要CAD风险因素分配权重的算法。目前的预测模型，包括FRS的发现已经建立，并促使寻找新的策略，以改善风险分层。几种方法已被用于测量研究人群中动脉粥样硬化的存在，并跟踪亚临床疾病的进展。许多具有高特异性和灵敏度，但具有侵入性和/或成本高。 胆固醇沉积在包括皮肤在内的脉管系统以外的组织中。它是皮肤的主要成分，并且包含11重量%的身体总含量的甜菜碱。皮肤组织胆固醇（SC）已被认为是反映与年龄和动脉粥样硬化相关的血管变化。最近，SC水平已被证明是显着相关的积极活动平板负荷试验和血管造影CAD。其他研究表明SC和循环炎症标志物与亚临床动脉粥样硬化之间存在关系。 此外，即使在调整年龄、性别和其他心脏危险因素后，SC仍与颈动脉IMT增加相关。在调整脆性风险评分后，SC与颈动脉IMT增加相关。这项多中心研究将在600名无症状受试者中确定皮肤胆固醇与颈动脉IMT之间的相关性，这些受试者通过FRS风险估计被选为低风险、中等风险和高风险。皮肤胆固醇也将与CAD风险的既定和新标志物进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple risk factors contribute to the development of atherosclerosis. The National Cholesterol Education Program provides guidleines for the prevention, diagnosis and management of coroanry aretery disease (CAD) based on the Framingham risk score (FRS), an algorithm that assigns weights to the major CAD risk factors . Uncertainties of the current predictive models, including FRS have been established and have prompted a search for new strategies to improve upon risk stratification. Several methods have been used to measure the presence of atherosclerosis in study populations and to track the progression of subclinical disease. Many have high specificity and sensitivity but are invasive and/or costly. Cholesterol is deposited in tissues other than the vasculature including skin. It is the major constituent of skin and comprises 11%, by weight, of total body content of choleseterol. Skin tissue cholesterol (SC) has been suggested to reflect vascular changes associated with age and atheroslcerosis. Recently SC levels have been shown to be significantly associated with positive treadmill stress tests and angiographic CAD. Additional studies have shown a relationship between SC and circulating inflammatory markers and subclinical atherosclerosis. In addition SC is associated with increased carotid IMT even after adjusting for age, sex and other cardiac risk factors. SC was associated with increased carotied IMT after adjustent for Framingham risk score. This multicenter study will determine the correlation between skin cholesterol and carotid IMT in 600 asymptomatic subjects selected as being low, intermediate and high risk by FRS risk estimate. Skin cholesterol will also be compared to established and novel markers of CAD risk.