PREDICTOR OF ADVANCED SUB-CLINICAL ATHEROSCLEROSIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 多种危险因素参与动脉粥样硬化的发生发展。国家胆固醇教育计划以Framingham Risk Score(FRS)为基础，为预防、诊断和管理冠状动脉疾病(CAD)提供指导，FRS是一种为主要的CAD风险因素分配权重的算法。目前的预测模型，包括FRS的不确定性已经建立，并促使人们寻找新的战略来改善风险分层。有几种方法被用来测量研究人群中动脉粥样硬化的存在，并跟踪亚临床疾病的进展。许多具有很高的特异性和敏感性，但具有侵入性和/或昂贵。胆固醇沉积在血管系统以外的组织中，包括皮肤。它是皮肤的主要成分，按重量计占总胆固醇量的11%。皮肤组织胆固醇(SC)被认为是反映与年龄和动脉粥样硬化相关的血管变化的指标。最近，SC水平已被证明与阳性的跑台负荷试验和血管造影术CAD显著相关。其他研究表明，SC和循环炎症标记物与亚临床动脉粥样硬化之间存在关系。此外，即使在调整了年龄、性别和其他心脏危险因素后，SC也与颈动脉IMT增加有关。经Framingham风险评分调整后，SC与颈动脉IMT增加相关。这项多中心研究将确定600名无症状受试者的皮肤胆固醇与颈动脉IMT的相关性，这些受试者被FRS风险估计选为低、中、高风险。皮肤胆固醇也将与已有的和新的冠心病风险标记物进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple risk factors contribute to the development of atherosclerosis. The National Cholesterol Education Program provides guidleines for the prevention, diagnosis and management of coroanry aretery disease (CAD) based on the Framingham risk score (FRS), an algorithm that assigns weights to the major CAD risk factors . Uncertainties of the current predictive models, including FRS have been established and have prompted a search for new strategies to improve upon risk stratification. Several methods have been used to measure the presence of atherosclerosis in study populations and to track the progression of subclinical disease. Many have high specificity and sensitivity but are invasive and/or costly. Cholesterol is deposited in tissues other than the vasculature including skin. It is the major constituent of skin and comprises 11%, by weight, of total body content of choleseterol. Skin tissue cholesterol (SC) has been suggested to reflect vascular changes associated with age and atheroslcerosis. Recently SC levels have been shown to be significantly associated with positive treadmill stress tests and angiographic CAD. Additional studies have shown a relationship between SC and circulating inflammatory markers and subclinical atherosclerosis. In addition SC is associated with increased carotid IMT even after adjusting for age, sex and other cardiac risk factors. SC was associated with increased carotied IMT after adjustent for Framingham risk score. This multicenter study will determine the correlation between skin cholesterol and carotid IMT in 600 asymptomatic subjects selected as being low, intermediate and high risk by FRS risk estimate. Skin cholesterol will also be compared to established and novel markers of CAD risk.