REGULATION OF VITAMIN D METABOLISM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是确定不同肤色的人对维生素D的每日需求量是否有所不同。维生素D可以从饮食中获得，也可以通过暴露在阳光下在皮肤中产生。然而，在深色皮肤的个体中，黑色素的数量增加会减少黑色素的产生，黑色素是赋予皮肤特有颜色的色素。某些人体内维生素D生成减少可能导致维生素D缺乏症。缺乏维生素D可能会增加患骨质疏松症或前列腺癌的风险。这项研究将招募100名参与者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine whether the daily requirement of vitamin D is different in individuals with different skin color. Vitamin D is obtained either from dietary sources or is produced in the skin by exposure to sunlight. However, in dark-skinned individuals, production is reduced by increased amounts of melanin, which is the pigment that gives the skin its characteristic color. The reduced vitamin D production, in some individuals, could result in vitamin D deficiency. Vitamin D deficiency may increase the risk for developing osteoporosis or prostate cancer. One hundred participants will be recruited for this study.