A PILOT STUDY TO EVALUATE NUCLEIC ACID AMPLIFICATION TESTS TO PREDICT TB RELAPSE

评估核酸扩增测试预测结核病复发的试点研究

• 批准号: 7627501
• 负责人: MARC H WEINER
• 金额: $ 0.79万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627501
• 关键词: Blinded; Centers for Disease Control and Prevention (U.S.); Computer Retrieval of Information on Scientific Projects Database; DNA; Enrollment; Evaluation; Funding; Grant; Informed Consent; Institution; Leukocytes; Measures; Messenger RNA; Nucleic Acid Amplification Tests; Nucleic Acids; Pilot Projects; Relapse; Research; Research Design; Research Personnel; Resources; Ribosomal RNA; Source; Specimen; Sputum; Testing; Time; Tuberculosis; United States National Institutes of Health; United States Public Health Service; Writing; inclusion criteria; treatment duration; treatment trial; tuberculosis treatment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: The aim of this study is to determine the utility of different nucleic acid amplification and broth culture tests obtained early in treatment and in the post-treatment periods to predict subsequent relapse of tuberculosis. Bacillary burden and MTB viability will be measured: in sputa by quantitative rRNA, qualitative (MTD Gen-Probe) rRNA, mRNA; 'time to positivity' in broth cultures; and in circulating leukocytes ("burry coat" specimens) by MTB DNA. RESEARCH PLAN: The study design is a blinded retrospective evaluation of specimens obtained in the course of two multi-center TB treatment trials. This is a CDC sponsored study. Inclusion criteria are (1) enrollment in TBTC / USPHS Trials 23 or 24, and (2) provision of written informed consent.

这个子项目是众多研究子项目之一