ACUPUNCTURE ANALGESIA, EXPECTANCY, AND PSYCHIATRIC COMORBIDITY IN PTS WIH LBP

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 镇痛是针灸和安慰剂中研究最多的治疗效果之一。涉及针灸止痛的临床随机对照试验(RCT)往往报告相互矛盾或模棱两可的结果，这往往是因为“对照”组显示出与针灸治疗组相同数量级的有益治疗效果[1-4]。相比之下，研究针灸和安慰剂止痛的基础科学研究已经产生了明确的结果[5-8]，这些结果导致了具体的可测试的机制假说。这项研究将在给予热痛之前针灸止痛的基础科学方法论应用于临床人群的下腰痛患者，同时监测缓解的预期和控制精神并发症。这是阐明针灸成败机制的第一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analgesia is one of the most studied therapeutic effects of both acupuncture and placebo. Clinical randomized controlled trials (RCTs) involving acupuncture for pain relief tend to report contradictory or equivocal outcomes often due to the fact that "control" groups exhibit beneficial treatment effects on the same order of magnitude as the acupuncture treatment groups [1-4]. In contrast, basic science research investigating both acupuncture and placebo analgesia has produced unequivocal results [5-8] that have led to specific testable mechanistic hypotheses. This study applies the basic science methodology of acupuncture analgesia prior to the administration of thermal pain to a clinical population of patients with low back pain, while monitoring expectations for relief and controlling for psychiatric comorbidity. This is a first step in elucidating mechanisms for success or failure of acupuncture.