ACUPUNCTURE ANALGESIA, EXPECTANCY, AND PSYCHIATRIC COMORBIDITY IN PTS WIH LBP

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 镇痛是针灸和安慰剂研究最多的治疗效果之一。涉及针灸缓解疼痛的临床随机对照试验 (RCT) 往往会报告矛盾或模棱两可的结果，通常是因为“对照组”表现出与针灸治疗组相同数量级的有益治疗效果 [1-4]。 相比之下，研究针灸和安慰剂镇痛的基础科学研究已经产生了明确的结果[5-8]，从而产生了具体的可测试的机制假设。 本研究将热痛治疗前针灸镇痛的基础科学方法应用于腰痛临床患者群体，同时监测缓解预期并控制精神合并症。 这是阐明针灸成功或失败机制的第一步。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Analgesia is one of the most studied therapeutic effects of both acupuncture and placebo. Clinical randomized controlled trials (RCTs) involving acupuncture for pain relief tend to report contradictory or equivocal outcomes often due to the fact that "control" groups exhibit beneficial treatment effects on the same order of magnitude as the acupuncture treatment groups [1-4]. In contrast, basic science research investigating both acupuncture and placebo analgesia has produced unequivocal results [5-8] that have led to specific testable mechanistic hypotheses. This study applies the basic science methodology of acupuncture analgesia prior to the administration of thermal pain to a clinical population of patients with low back pain, while monitoring expectations for relief and controlling for psychiatric comorbidity. This is a first step in elucidating mechanisms for success or failure of acupuncture.