LICIT AND ILLICIT OPIOIDS: COMPARATIVE STUDIES IN HUMANS: STUDY 1

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在散发性阿片类药物滥用者中，描述全剂量范围内口服羟考酮的药效学特性。在散发性阿片类药物滥用者中，描述全剂量范围内口服氢可酮的药效学特性。通过将羟考酮和氢可酮与氢吗啡酮（一种已知高滥用可能性的阿片类药物）和安慰剂进行比较，表征羟考酮和氢可酮在人群中的相对滥用可能性。我们假设这三种药物都会产生与滥用倾向相关的主观特征。这些药物的生理效力与其滥用倾向之间将存在脱节。产生生理等效作用的剂量，产生与滥用倾向相关的主观作用的相对效力在大小上不同，其中氢吗啡酮>羟考酮>氢可酮。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the pharmacodynamic properties of oral oxycodone across a full range of doses in sporadic opioid abusers. To characterize the pharmacodynamic properties of oral hyrocodone across a full range of doses in sporadic opioid abusers. To characterize the relative abuse potential of oxycodone and hydrocodone in the population by comparing it to hydromorphone, an opioid of know high abuse potential, and placebo. We hypothesis that all three drugs will produce a subjective profile associated with abuse liability. There will be a disassociation between the physiological potency of these drugs and their abuse liability profile. Doses producing physiologically equivaltent effects, the relative potency for producing subjective effects related to abuse liabiilty differ in magnitude whereby hydromorphone> oxycodone> hydrocodone.