MACROMOLECULAR X-RAY CRYSTALLOGRAPHY CORE B

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Essential to the design of new therapies against emerging bacterial threats is the determination of the three-dimensional structure of potential protein targets. Macromolecular x-ray crystallography provides a powerful experimental tool that allows us to obtain that necessary structural information. The wealth of information contained within the structural data can subsequently be utilized in the determination of the important relationship between protein structure and function. Utilization of this data will lead directly to the formulation of new mechanisms to control bacterial pathogenesis.