TEEN WT LOSS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青少年布朗克斯营养和健身倡议（B 'N FIT）计划是多方面的，并针对青少年的发展水平。 我们将进行一项随机临床试验，旨在评估6个月后B 'N FIT计划干预的有效性，并与仅接受标准医疗护理的对照组进行比较。结果指标包括以下方面的变化： 人体测量（体重、体重指数（BMI）、腰围和颈围） 2型糖尿病的生化标志物（胰岛素、葡萄糖、口服葡萄糖耐量试验（OGTT）、微量白蛋白尿） 与肥胖相关的心血管危险因素（收缩压、舒张压、LDL、HDL和甘油三酯、C-反应蛋白、同型半胱氨酸、22-26脂蛋白（a）、27 -30载脂蛋白B。）27-30 健身 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 我们假设，六个月后，B 'N FIT参与者将显示出显着改善，在许多这些结果的措施相比，对照组。本研究的结果将用于开发一项申请，以资助：a）使用较大样本量对B 'N FIT进行1年和3年评价;以及B）评价单个B' B FIT组件的价值和成本效益以及对各种结局指标的长期影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Bronx Nutrition and Fitness Initiative for Teens (B'N FIT) program is multifaceted and tailored to the developmental level of adolescents. We will conduct a randomized clinical trial designed to evaluate the effectiveness of the B'N FIT program intervention after six months compared to a control group receiving standard medical care alone. Outcome measures include changes in: Anthropometric measurements (weight, body mass index (BMI), waist, and neck circumference) Biochemical markers of type 2 diabetes mellitus (insulin, glucose, oral glucose tolerance test (OGTT), microalbuminuria) Cardiovascular risk factors associated with obesity (systolic blood pressure, diastolic blood pressure, LDL, HDL, and triglycerides, C-reactive protein, homocysteine,22-26 lipoprotein(a),27-30 apolipoprotein B.)27-30 Fitness 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. 5. We hypothesize that after six months B'N FIT participants will show significant improvement in many of these outcome measures when compared with the control group. The results of this study will be used to develop an application to fund: a) a one and three year evaluation of B'N FIT using a larger sample size; and b) evaluation of the value and cost-effectiveness of individual B'B FIT components and the long term effects on the various outcome measures.