KEEPS DDM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这是在随机接受经皮雌激素、口服雌激素/口服孕酮或匹配安慰剂的绝经后早期女性中进行的KEEPS研究（Kronos扩展雌激素预后研究）的代谢子研究。结果变量包括雌激素替代对胰岛素分泌、肝脏和外周胰岛素敏感性的影响，如通过混合餐耐量试验五重示踪法测定的碳水化合物代谢、肝脏血浆流量和胰岛素分泌率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a metabolic substudy to the KEEPS study (Kronos Extended Estrogen Progesterone Study) in early post menopausal women randomized to transdermal estrogen, oral estrogen/oral progesterone or matching placebo. Outcome variables include the effects of estrogen replacement on insulin secretion, hepatic and peripheral insulin sensitivity as measured by the mixed meal tolerance test quintuple tracer methodology of carbohydrate metabolism, hepatic plasma flow and insulin secretion rates.