Adherence to HCV Treatment in HCV and HCV/HIV Patients

HCV 和 HCV/HIV 患者对 HCV 治疗的依从性

• 批准号: 7567550
• 负责人: JEFFREY J WEISS
• 金额: $ 15.16万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-04 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7567550
• 关键词: Adherence; Adverse effects; Alcohol or Other Drugs use; Behavioral Sciences; Biological; Clinical; Cohort Studies; Decision Making; Development; Diagnosis; Early treatment; Enrollment; Ethics; Goals; Grant; HIV; HIV Infections; HIV therapy; Health Policy; Hepatitis C; Hepatitis C virus; Injecting drug user; Interferon-alpha; Intervention; Interview; K-Series Research Career Programs; Knowledge; Lead; Measurement; Medical; Mentors; Modeling; National Institute of Mental Health; Neurocognitive; Patients; Persons; Pharmaceutical Preparations; Physicians; Policy Maker; Population; Principal Investigator; Process; Prospective Studies; Psychologist; Public Health; Randomized Clinical Trials; Recruitment Activity; Research; Research Methodology; Research Personnel; Resources; Retrospective Studies; Ribavirin; Sampling; Schedule; Self Efficacy; Structure; Substance Use Disorder; Substance abuse problem; Time; Training; Treatment Efficacy; Writing; career; depression; effective intervention; effective therapy; efficacy testing; experience; improved; neuropsychiatry; patient oriented; programs; prospective; statistics; success; therapy development; treatment strategy

DESCRIPTION (provided by applicant): This application for an NIMH Mentored Patient-Oriented Career Development Award (K23), titled "Adherence to HCV Treatment in HCV and HCV/HIV Patients," seeks to develop the Principal Investigator (PI), a clinical psychologist, into an independent investigator performing research with nonadherent medically ill patients with comorbid psychiatric and substance use disorders. The short-term career goals of the PI include obtaining (1) knowledge of the diagnosis and treatment of HCV and HIV infections, (2) knowledge of the measurement of adherence and of the biological consequences of non-adherence, (3) training in substance abuse-related issues and neurocognitive aspects of HIV/HCV and substance abuse (4) training in research methodology, statistics, grant writing (5) training in public health and policy aspects of research on (former) injection drug users, (6) training in the conduct of ethical research, (7) training in the administration of structured psychiatric interview schedules. The long-term goals of the PI include conducting research on the impact of comorbid medical and psychiatric conditions on adherence to medical treatment, particularly with HCV and HCV/HIV patients. The research proposed is a prospective cohort study in which 100 HCV and 100 HCV/HIV patients will be enrolled just prior to initiating HCV therapy with pegylated IFN-alfa and ribavirin (PEG-IFN/RBV). Treatment with PEG-IFN/RBV is associated with numerous hematologic, physical, and neuropsychiatric side effects, which lead to high rates of early treatment discontinuation. The 200 recruited patients will be followed for the first 24 weeks of treatment to determine whether depression, neurocognitive functioning, substance abuse and treatment self-efficacy are associated with early treatment discontinuation in these two groups of patients and whether the two groups differ in rates of early treatment discontinuation. The findings of this study will have important implications for the development of interventions to support and assist HCV and HCV/HIV patients in completing their course of PEG-IFN/RBV treatment.

描述（由申请人提供）：NIMH指导的以患者为导向的职业发展奖（K23）的申请，题为“坚持HCV和HCV/HIV患者的HCV治疗”，旨在将主要研究者（PI），临床心理学家，发展成为一名独立的研究者，对患有精神病和物质使用障碍的非依从性医学疾病患者进行研究。PI的短期职业目标包括获得（1）HCV和HIV感染的诊断和治疗知识，（2）依从性测量和不依从的生物学后果的知识，（3）药物滥用相关问题和HIV/HCV和药物滥用的神经认知方面的培训（4）研究方法学，统计学，赠款写作（5）关于（前）注射吸毒者研究的公共卫生和政策方面的培训，（6）进行伦理研究的培训，（7）管理结构化精神病学访谈时间表的培训。PI的长期目标包括研究共病医学和精神疾病对药物治疗依从性的影响，特别是HCV和HCV/HIV患者。该研究是一项前瞻性队列研究，其中100名HCV和100名HCV/HIV患者将在开始用聚乙二醇化IFN-α和利巴韦林（PEG-IFN/RBV）治疗HCV之前入组。用PEG-IFN/RBV治疗与许多血液学、身体和神经精神方面的副作用相关，这导致早期治疗中止率高。将在治疗的前24周对200例招募的患者进行随访，以确定抑郁、神经认知功能、药物滥用和治疗自我效能是否与这两组患者的早期治疗中止相关，以及两组患者的早期治疗中止率是否存在差异。这项研究的结果将有重要意义的干预措施的发展，以支持和协助HCV和HCV/HIV患者完成他们的PEG-IFN/RBV治疗过程中。

项目成果

Hepatitis C patients' self-reported adherence to pegylated interferon and ribavirin.

丙型肝炎患者自我报告坚持使用聚乙二醇干扰素和利巴韦林。

• 发表时间: 2008
• 期刊: Alimentary pharmacology & therapeutics
• 影响因子: 7.6
• 作者: Weiss,JJ;Bhatti,L;Dieterich,DT;Edlin,BR;Fishbein,DA;Goetz,MB;Yu,K;Wagner,GJ
• 通讯作者: Wagner,GJ

The critical role of medication adherence in the success of boceprevir and telaprevir in clinical practice.

药物依从性对于博普瑞韦和特拉匹韦在临床实践中取得成功的关键作用。

• DOI: 10.1016/j.jhep.2011.05.014
• 发表时间: 2012
• 期刊: Journal of hepatology
• 影响因子: 25.7
• 作者: Weiss,JeffreyJ;Alcorn,MarleneC;Rabkin,JudithG;Dieterich,DouglasT
• 通讯作者: Dieterich,DouglasT

Psychiatric management of HIV/HCV-coinfected patients beginning treatment for hepatitis C virus infection: survey of provider practices.

开始治疗丙型肝炎病毒感染的 HIV/HCV 合并感染患者的精神科管理：对提供者实践的调查。

• DOI: 10.1016/j.genhosppsych.2009.05.006
• 发表时间: 2009
• 期刊: General hospital psychiatry
• 影响因子: 7
• 作者: Weiss,JeffreyJ;Morgello,Susan
• 通讯作者: Morgello,Susan

Multimethod assessment of baseline depression and relationship to hepatitis C treatment discontinuation.

基线抑郁症及其与丙型肝炎治疗中断的关系的多方法评估。

• DOI: 10.1177/0091217417749796
• 发表时间: 2018
• 期刊: International journal of psychiatry in medicine
• 影响因子: 2
• 作者: Weiss,JeffreyJ;Prieto,Sarah;Bräu,Norbert;Dieterich,DouglasT;Marcus,SueM;Stivala,Alicia;Gorman,JackM
• 通讯作者: Gorman,JackM

Psychiatric behavioral aspects of comanagement of hepatitis C virus and HIV.

丙型肝炎病毒和艾滋病毒共同管理的精神行为方面。

• DOI: 10.1007/s11904-006-0013-2
• 发表时间: 2006
• 期刊: Current HIV/AIDS reports
• 影响因子: 4.6
• 作者: Weiss,JeffreyJ;Gorman,JackM
• 通讯作者: Gorman,JackM