ULTRASOUND MEASUREMENT OF TUMOR MICROCIRCULATION AND PERFUSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 仅活体动物数据。我们正在做一系列的研究，看看辐射，热疗和含药脂质体对肿瘤生长延迟的影响。我们计划处死动物进行组织学检查，但希望在治疗前后获得肿瘤体积和多普勒图像，以观察肿瘤灌注的变化。 理想情况下，当微泡可用时，我们希望对动物微循环进行成像，以寻找可能由使用辐射和/或药物引起的结构变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Live animal data only. We are doing a serial study to look at the effect of radiation, hyperthermia, and drug-containing liposomes on tumor growth delay. We plan to sacrifice animals for histology, but would like images of tumor volume and doppler prior and post treatment to observed changes in tumor perfusion. Idealy when the micro bubbles are available we would like to image the animals microcirculation to look for architecture changes that can result from the use of radiation and/or drug.