ULTRASOUND MEASUREMENT OF TUMOR MICROCIRCULATION AND PERFUSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 仅限活体动物数据。我们正在进行一系列研究，以观察放射、热疗和含药脂质体对肿瘤生长延迟的影响。我们计划牺牲动物以进行组织学研究，但希望通过治疗前后肿瘤体积和多普勒的图像来观察肿瘤血流的变化。理想情况下，当微泡可用时，我们希望对动物的微循环进行成像，以寻找辐射和/或药物的使用可能导致的结构变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Live animal data only. We are doing a serial study to look at the effect of radiation, hyperthermia, and drug-containing liposomes on tumor growth delay. We plan to sacrifice animals for histology, but would like images of tumor volume and doppler prior and post treatment to observed changes in tumor perfusion. Idealy when the micro bubbles are available we would like to image the animals microcirculation to look for architecture changes that can result from the use of radiation and/or drug.