MOLECULAR DYNAMICS SIMULATIONS OF THE GLUTAMATE RECEPTOR TETRAMER STRUCTURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 关键词：谷氨酸受体，分子生物学，四聚体。 摘要： 配体门控谷氨酸受体（GluR）离子通道介导神经系统中的突触信号。当发现谷氨酸时，通道打开至配体结合结构域。我们已经分析了单结合结构域的结构。现在我们要模拟四聚体结构，当四个亚基组装形成离子通道的细胞外部分时。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Keywords: Glutamate receptor, MD, tetramer. Abstract: Ligand-gated Glutamate Receptor (GluR) ion channels mediate synaptic signals in the nervous system. The channel opens upon finding of the glutamate to the ligand binding domains. We already analyzed the structure of single binding domain. Now we are going to simulate the tetrameric structure when four subunits are assembled to form extracellular part of the ion channel.