PEPTIDE SURROGATES IN RAPID SYNTHESIS OF HIV PROTEASE INHIBITORS
快速合成 HIV 蛋白酶抑制剂中的肽替代物
基本信息
- 批准号:7601717
- 负责人:
- 金额:$ 0.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:AchievementAmidesBiologicalComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentFundingGoalsGrantInstitutionLaboratoriesNatureObject AttachmentPeptidesPharmaceutical PreparationsPropertyProtease InhibitorResearchResearch PersonnelResourcesSourceUnited States National Institutes of Healthabsorptioncombinatorialimprovedinhibitor/antagonistlipophilicitynovel
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Given the ubiquitous nature of the peptide linkage in biological molecules, replacement of the amide bond with isosteres in potential drug candidates has been a continual goal of many laboratories. Successful replacements will provide improved stability, lipophilicity, and absorption. Many surrogates have been introduced already, yet the synthesis of many of these isosteres in a combinatorial way is difficult and requires several steps. Thus, the discovery of new peptide surrogates with easier syntheses is an important achievement that could open new opportunities for the study of amide-containing molecules and the development of inhibitors with novel physicochemical properties.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
鉴于生物分子中普遍存在的肽键的性质,在潜在的候选药物中用电子等排体取代酰胺键一直是许多实验室的持续目标。成功的替代品将提供改善的稳定性、亲脂性和吸收。已经引入了许多替代物,但以组合方式合成许多这些等排体是困难的,需要几个步骤。因此,发现新的肽替代物,更容易合成是一个重要的成就,可以打开新的机会,研究含酰胺的分子和开发具有新的物理化学性质的抑制剂。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CHI-HUEY WONG其他文献
CHI-HUEY WONG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CHI-HUEY WONG', 18)}}的其他基金
Targeting Influenza A Virus by a Carbohydrate-inspired Strategy
通过碳水化合物启发的策略针对甲型流感病毒
- 批准号:
10239014 - 财政年份:2019
- 资助金额:
$ 0.76万 - 项目类别:
Targeting Influenza A Virus by a Carbohydrate-inspired Strategy
通过碳水化合物启发的策略针对甲型流感病毒
- 批准号:
10458665 - 财政年份:2019
- 资助金额:
$ 0.76万 - 项目类别:
Targeting Influenza A Virus by a Carbohydrate-inspired Strategy
通过碳水化合物启发的策略针对甲型流感病毒
- 批准号:
10020313 - 财政年份:2019
- 资助金额:
$ 0.76万 - 项目类别:
PEPTIDE SURROGATES IN RAPID SYNTHESIS OF HIV PROTEASE INHIBITORS
快速合成 HIV 蛋白酶抑制剂中的肽替代物
- 批准号:
7955262 - 财政年份:2009
- 资助金额:
$ 0.76万 - 项目类别:
PEPTIDE SURROGATES IN RAPID SYNTHESIS OF HIV PROTEASE INHIBITORS
快速合成 HIV 蛋白酶抑制剂中的肽替代物
- 批准号:
7722370 - 财政年份:2008
- 资助金额:
$ 0.76万 - 项目类别:
相似海外基金
Collaborative Research: NSF-DFG: CAS: Electrochemical Hydrogenation of Amides and Esters
合作研究:NSF-DFG:CAS:酰胺和酯的电化学氢化
- 批准号:
2140205 - 财政年份:2022
- 资助金额:
$ 0.76万 - 项目类别:
Standard Grant
Collaborative Research: NSF-DFG: CAS: Electrochemical Hydrogenation of Amides and Esters
合作研究:NSF-DFG:CAS:酰胺和酯的电化学氢化
- 批准号:
2140196 - 财政年份:2022
- 资助金额:
$ 0.76万 - 项目类别:
Standard Grant
Atroposelective Synthesis of Hindered Amides - Exploration of Synthetic Peptide Catalysts -
受阻酰胺的天体选择性合成-合成肽催化剂的探索-
- 批准号:
504378162 - 财政年份:2022
- 资助金额:
$ 0.76万 - 项目类别:
WBP Fellowship
Development of Peptide Chemical Modification Enabled by N-Halogenation of Amides
酰胺 N-卤化实现的肽化学修饰的发展
- 批准号:
22H02743 - 财政年份:2022
- 资助金额:
$ 0.76万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Modulating Signaling Endocannabinoids and Fatty Acid Amides
调节信号传导内源性大麻素和脂肪酸酰胺
- 批准号:
10532252 - 财政年份:2021
- 资助金额:
$ 0.76万 - 项目类别:
CAREER: SusChEM: Iron Catalysts for the Reduction of Amides
职业:SusChEM:用于还原酰胺的铁催化剂
- 批准号:
2146728 - 财政年份:2021
- 资助金额:
$ 0.76万 - 项目类别:
Continuing Grant
Modulating Signaling Endocannabinoids and Fatty Acid Amides
调节信号传导内源性大麻素和脂肪酸酰胺
- 批准号:
10399712 - 财政年份:2021
- 资助金额:
$ 0.76万 - 项目类别:
Nickel-Catalyzed Alpha-Arylation of Secondary Amides
镍催化仲酰胺的α-芳基化
- 批准号:
558383-2020 - 财政年份:2020
- 资助金额:
$ 0.76万 - 项目类别:
Canadian Graduate Scholarships Foreign Study Supplements
Function of primary fatty acid amides as lipid mediators
伯脂肪酸酰胺作为脂质介质的功能
- 批准号:
20K21285 - 财政年份:2020
- 资助金额:
$ 0.76万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Improving selectivity in Ni-catalyzed activation of amides
提高镍催化酰胺活化的选择性
- 批准号:
518319-2018 - 财政年份:2020
- 资助金额:
$ 0.76万 - 项目类别:
Postgraduate Scholarships - Doctoral