PEPTIDE SURROGATES IN RAPID SYNTHESIS OF HIV PROTEASE INHIBITORS

快速合成 HIV 蛋白酶抑制剂中的肽替代物

• 批准号: 7601717
• 负责人: CHI-HUEY WONG
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601717
• 关键词: Achievement; Amides; Biological; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Goals; Grant; Institution; Laboratories; Nature; Object Attachment; Peptides; Pharmaceutical Preparations; Property; Protease Inhibitor; Research; Research Personnel; Resources; Source; United States National Institutes of Health; absorption; combinatorial; improved; inhibitor/antagonist; lipophilicity; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Given the ubiquitous nature of the peptide linkage in biological molecules, replacement of the amide bond with isosteres in potential drug candidates has been a continual goal of many laboratories. Successful replacements will provide improved stability, lipophilicity, and absorption. Many surrogates have been introduced already, yet the synthesis of many of these isosteres in a combinatorial way is difficult and requires several steps. Thus, the discovery of new peptide surrogates with easier syntheses is an important achievement that could open new opportunities for the study of amide-containing molecules and the development of inhibitors with novel physicochemical properties.

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