Modelling the regulation of nephron number by the renal stem cell niche.

模拟肾干细胞生态位对肾单位数量的调节。

• 批准号: nhmrc : 1002748
• 负责人: Dr Nicholas Hamilton
• 金额: $ 47.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modelling-regulation-nephron-cell-niche/108858
• 关键词: Modelling; regulation; nephron; number; renal

Chronic kidney disease is a growing burden to the health system. The long term health of your kidneys is influenced by the number of functional units, nephrons, present in each kidney, a feature that is determined before birth. If we could influence this number, we may be able to reduce the risk of kidney disease in later life for at risk populations, including the Aboriginal community. This study will investigate the stem cells that form the nephrons, how the process occurs and how it can be influenced.

慢性肾脏疾病对卫生系统来说是一个日益沉重的负担。肾脏的长期健康受到每个肾脏中存在的功能单位(肾单位)的数量的影响，这是在出生之前就确定的特征。如果我们能够影响这个数字，我们可能能够降低高危人群，包括土著社区在以后的生活中患肾脏疾病的风险。这项研究将研究形成肾单位的干细胞，这个过程是如何发生的，以及它是如何受到影响的。