NEURAL CORRELATES OF ATTENTIONAL CONTROL OF CONFLICT PROCESSING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 导言： 为了用fMRI识别冲突处理和注意分配的神经回路，我们设计了一项Stroop匹配到样本任务，要求根据颜色线索做出决定，该颜色线索将注意力引导到特定颜色并启动刺激的颜色处理。 健康的右撇子成年志愿者在执行Stroop匹配到样本任务时进行了功能磁共振成像。受试者将屏幕中央的提示刺激的颜色与Stroop目标刺激的颜色相匹配。颜色提示与Stroop目标的颜色匹配或不匹配，Stroop目标的颜色要么一致(用蓝色墨水写的蓝色字)，要么不一致(用红色墨水写的蓝色字)。给出了两次运行，每次运行18个数据块(TR=2.2秒)。Stroop冲突处理与审判前颜色提示(匹配)在涉及左侧ACC、STG、d-PCC和右侧顶叶皮质的额顶叶注意网络中的大胆信号增加相关。匹配对比度(不匹配与匹配线索-目标颜色)主要与d-PCC激活有关。 结论： 这一范式提供了额叶-顶叶注意系统的一种新的区分，并为临床研究识别注意力神经系统中断的来源奠定了基础。 资金来源 这项工作得到了NIAAA赠款的支持：AA10723，AA05965 相关出版物 《Pfefferbaum A，Adalsteinsson E，Sullivan EV(2006)》。生物精神病学，59：364-372。 “舒尔特·T，M？ler-Oehring EM，RosenBloom MJ，Pfefferbaum A，Sullivan EV(2005).生物精神病学，57：67-75.” 《舒尔特，T，M？ler-Oehring，EM，Salo，R，Pfefferbaum，A，Sullivan，EV(2006)》。神经心理学，20：727-736。 “Sullivan EV，Pfefferbaum(2005).精神药理学，180：583-94.

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: To identify the neural circuits of conflict processing and attentional allocation with fMRI, we devised a Stroop Match-to-Sample task requiring a decision based on a color cue that directs attention to a specific color and primes the color processing of the stimulus. Healthy right-handed adult volunteers underwent fMRI while performing the Stroop Match-to-Sample task. Subjects matched the color of a cue stimulus in the center of the screen to the color of a Stroop target stimulus. The color cue either matched or did not match the color of the Stroop target, which was either congruent (word blue written in blue ink) or incongruent (word blue written in red ink). Two runs were presented with 18 blocks per run (TR = 2.2 sec). Stroop conflict processing with pretrial color cueing (Match) was associated with BOLD signal increases in a fronto-parietal attention network involving the left ACC, STG, d- PCC and the right parietal cortex. The Match contrast (nonmatch vs. match cue-target color) was mainly associated with d-PCC activation. Conclusion: This paradigm provides a novel differentiation of frontal-parietal attention systems and lays a foundation for clinical research on identifying sources of disruption of neural systems of attention. Funding Sources " This work was supported by NIAAA grants: AA10723, AA05965 Relevant publications " Pfefferbaum A, Adalsteinsson E, Sullivan EV (2006). Biol Psychiatry, 59:364-372. " Schulte T, M¿ller-Oehring EM, Rosenbloom MJ, Pfefferbaum A, Sullivan EV (2005). Biol Psychiatry, 57:67-75. " Schulte, T, M¿ller-Oehring, EM, Salo, R, Pfefferbaum, A, Sullivan, EV (2006). Neuropsychology, 20:727-736. " Sullivan EV, Pfefferbaum (2005). Psychopharmacology, 180:583-94.