NEURAL CORRELATES OF ATTENTIONAL CONTROL OF CONFLICT PROCESSING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 简介： 为了用fMRI识别冲突处理和注意分配的神经回路，我们设计了一个Stroop匹配样本任务，该任务需要基于颜色线索的决策，该颜色线索将注意力引导到特定的颜色并启动刺激的颜色处理。 健康的右撇子成年志愿者在执行Stroop匹配样本任务时接受了fMRI。受试者将屏幕中央的提示刺激的颜色与Stroop目标刺激的颜色相匹配。颜色线索要么与Stroop目标的颜色匹配，要么不匹配，要么一致（用蓝色墨水写的蓝色单词），要么不一致（用红色墨水写的蓝色单词）。提供了两次运行，每次运行18个组织块（TR = 2.2秒）。Stroop冲突处理与审判前颜色线索（匹配）与BOLD信号增加额顶叶注意网络，涉及左ACC，STG，d- PCC和右顶叶皮层。匹配对比度（非匹配与匹配线索-目标颜色）主要与d-PCC激活相关。 结论： 这种范式提供了一种新的分化额顶叶注意系统，并奠定了基础，为临床研究确定干扰源的神经系统的注意。 资金来源 " 这项工作得到了NIAAA赠款：AA 10723，AA 05965 相关出版物 " Pfefferbaum A，Adalsteinsson E，Sullivan EV（2006）. Biol Psychiatry，59：364-372. " Schulte T，M？ller-Oehring EM，Rosenbloom MJ，Pfefferbaum A，Sullivan EV（2005）. Biol Psychiatry，57：67-75. " Schulte，T，M萨洛，R，Pfefferbaum，A，Sullivan，EV（2006）. Neuropsychology，20：727-736. " Sullivan EV，Pfefferbaum. Psychopharmacology，180：583-94.

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: To identify the neural circuits of conflict processing and attentional allocation with fMRI, we devised a Stroop Match-to-Sample task requiring a decision based on a color cue that directs attention to a specific color and primes the color processing of the stimulus. Healthy right-handed adult volunteers underwent fMRI while performing the Stroop Match-to-Sample task. Subjects matched the color of a cue stimulus in the center of the screen to the color of a Stroop target stimulus. The color cue either matched or did not match the color of the Stroop target, which was either congruent (word blue written in blue ink) or incongruent (word blue written in red ink). Two runs were presented with 18 blocks per run (TR = 2.2 sec). Stroop conflict processing with pretrial color cueing (Match) was associated with BOLD signal increases in a fronto-parietal attention network involving the left ACC, STG, d- PCC and the right parietal cortex. The Match contrast (nonmatch vs. match cue-target color) was mainly associated with d-PCC activation. Conclusion: This paradigm provides a novel differentiation of frontal-parietal attention systems and lays a foundation for clinical research on identifying sources of disruption of neural systems of attention. Funding Sources " This work was supported by NIAAA grants: AA10723, AA05965 Relevant publications " Pfefferbaum A, Adalsteinsson E, Sullivan EV (2006). Biol Psychiatry, 59:364-372. " Schulte T, M¿ller-Oehring EM, Rosenbloom MJ, Pfefferbaum A, Sullivan EV (2005). Biol Psychiatry, 57:67-75. " Schulte, T, M¿ller-Oehring, EM, Salo, R, Pfefferbaum, A, Sullivan, EV (2006). Neuropsychology, 20:727-736. " Sullivan EV, Pfefferbaum (2005). Psychopharmacology, 180:583-94.