RENAL TRANSPLANTATION IN CROSSMATCH POSITIVE RECIPIENTS

交叉匹配阳性受者的肾移植

• 批准号: 7604190
• 负责人: Darshana Dadhania
• 金额: $ 0.08万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604190
• 关键词: Antibodies; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Institution; Intravenous Immunoglobulins; Kidney Transplantation; Living Donors; Organ Transplantation; Patients; Registries; Research; Research Personnel; Resources; Risk; Source; Time; Transplantation; Treatment Protocols; United Network for Organ Sharing; United States National Institutes of Health; mycophenolate mofetil; rituximab

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The presence of donor-specific antibodies present a significant barrier to organ transplantation due the risk for development of hyperacute or accelerated rejection leading to graft loss. UNOS registry demonstrates that the average waiting time of sensitized patients is more than twice those who are not sensitized and some may never receive a transplant. The aim of this study is to decrease the sensitization level of these patients by studying a pre-treatment regimen consisting of IVIG, Mycophenolate Mofetil (MMF), and Rituximab to desensitize patients with positive crossmatches and allow successful living donor renal transplantation in patients who have limited options.

这个子项目是众多研究子项目之一