THE ROLE OF PROCOLLAGEN 1 AND TGF-BETA 1 IN CYSTICFIBROTIC PULMONARY DISEASE

原胶原 1 和 TGF-β 1 在囊性纤维化肺疾病中的作用

• 批准号: 7604280
• 负责人: MANU JAIN
• 金额: $ 0.64万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604280
• 关键词: ROLE; PROCOLLAGEN; TGF; BETA; CYSTICFIBROTIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cystic fibrosis (CF) is the most common lethal genetic disease among Caucasians. Histopathologic and ultrastructural studies of lungs from CF patients have revealed submucosal inflammation with neutrophils, lymphocytes and plasma cells as well submucosal matrix destruction and repair. Both collagen I and collagen III have are present in the subepithelial fibrosis layer. TGF-b polymorphisms have been linked to outcome in CF and TGF-b1 has been reported to be present in the CF airway. TGF-b is a member of a family of polypeptide growth factors which modulate inflammatory cell function as well as extracellular matrix production. In this proposal we will determine if sputum from CF patients can upregulate procollagen I production and this is due to TGF-b1. In addition we will determine if the degree of procollagen 1 upregulation or TGF-b1 levels are associated with clinical outcome.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 囊性纤维化（CF）是白种人中最常见的致死性遗传病。 CF患者肺的组织学和超微结构研究揭示了中性粒细胞、淋巴细胞和浆细胞的粘膜下炎症以及粘膜下基质破坏和修复。 胶原蛋白I和胶原蛋白III都存在于上皮下纤维化层中。 TGF-b多态性与CF的结局有关，并且据报道TGF-b1存在于CF气道中。 TGF-β是调节炎性细胞功能以及细胞外基质产生的多肽生长因子家族的成员。 在这个建议中，我们将确定CF患者的痰液是否可以上调I型前胶原的产生，这是由于TGF-β 1。 此外，我们还将确定前胶原1上调的程度或TGF-β 1水平是否与临床结果相关。