Modulating COVID-19 disease by targeting virus and virus-induced responses through pharmaceutical and mechanical ventilation strategies: SARS-CoV-2 S-protein, ACE2 and TMPRSS2

新冠肺炎是目前的一种全球性流行病，很可能是一个持续的威胁。我们需要多管齐下的战略来对抗新冠肺炎，包括治疗性抗病毒药物和临床实践管理战略。我们将解决这两个问题，以定义疾病的触发机制，测试现有的针对雄激素的药物，并修改医生在重症监护病房使用呼吸机治疗新冠肺炎病的方式。在管理病毒性肺病方面，结果将产生超出新冠肺炎范围的影响。

COVID-19 is a current global pandemic that is likely to be an on-going threat. We need a multipronged strategy to combat COVID-19, including therapeutic anti-virals and clinical practice management strategy. We will address both these points to define the mechanisms triggering disease, test existing drugs targeting androgens and modify the way doctors use ventilators to treat COVID-19 disease in the intensive care unit. Outcomes will have impact beyond COVID-19 for managing viral lung disease.