权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Maternal HIV: Intervention to Assist Disclosure to Children

孕产妇艾滋病毒：协助向儿童披露艾滋病毒信息的干预措施

基本信息

批准号：
7545838
负责人：
DEBRA A. MURPHY
金额：
$ 25.22万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-01 至 2010-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7545838
关键词：
12 year old AIDS/HIV problem Acting Out Address Age Behavior Characteristics Child Child Mental Health Communication Control Groups Data Demographic Factors Disclosure Ethnic Origin Evaluation Family Gender HIV HIV Seropositivity Health Status Health behavior Individual Intervention Interview Knowledge Learning Life Mediating Mental Health Modeling Modification Mothers Outcome Parent-Child Relations Parenting behavior Parents Participant Perception Pharmaceutical Preparations Prevention Problem behavior Procedures Process Randomized Readiness Research Research Personnel School-Age Population Severity of illness Stigmata Stress Telephone Testing Time Training Treatment Efficacy Woman Work base design experience follow-up improved information gathering information processing longitudinal design medication compliance parent-child communication primary outcome programs prospective psychological distress secondary outcome skills social stigma therapy development

项目摘要

DESCRIPTION (provided by applicant): The purpose of this small 3-year R01 is to test the preliminary efficacy of an intervention to assist HIV- infected mothers to disclose their serostatus to their young (age 6-12 year old), well children. The basis for development of this intervention is work from two R01s (MH # 5R01MH057207, currently Yr. 09) designed to longitudinally assess HIV-positive mothers and their children, which included studies on maternal disclosure (e.g., Murphy, Marelich, & Hoffman, 2002; Murphy, Marelich, Hoffman, & Schuster, 2006; Murphy, Roberts, & Hoffman, 2002; Murphy, Roberts, & Hoffman, 2003; Murphy, Roberts, & Hoffman, 2006; Murphy, Steers, & Dello Stritto, 2001). This research suggests disclosure is difficult for mothers living with HIV (MLWHs), and that outcomes for both mothers and children could be improved by the proposed intervention. Information gathered in the previous two R01s will be used to develop a brief disclosure intervention. MLWHs (N = 80) will be randomly assigned to the intervention or control condition. MLWHs and children (N = 160) will be assessed at baseline, 3, 6, and 9-month follow-ups. A random subset of intervention mothers (n = 12) will be asked to participate in an in-depth qualitative interview after their last follow-up, to obtain detailed process information on their experiences in the study. The aims of the intervention are to: improve mother-child communication and parenting skills-particularly as they relate to disclosure. As a result of the intervention aims, other primary and secondary outcomes include: increasing readiness to disclose, and disclosure itself; improving both MLWH and child mental health indicators; reducing child behavioral problems, and improving the parent-child relationship and family functioning. This study will provide important prospective, longitudinal data on MLWHs' adjustment to having disclosed their serostatus, and their children's adjustment to the disclosure. Previous research indicates that for some families, maternal and child psychological distress may increase immediately following disclosure, but will decrease over time; the longitudinal design of this study will allow us to follow mothers and children throughout the disclosure process. The study will allow evaluation of maternal and child characteristics that may moderate or mediate the impact of disclosure. Finally, process evaluations for each intervention session as well as in-depth qualitative interviews with a subset of MLWHs who attended the intervention will provide information on issues that need to be addressed prior to a full-scale trial of the disclosure intervention. Few interventions, other than for prevention or medication adherence, are available for women living with HIV; this study will evaluate an intervention that will help HIV-positive mothers deal with a serious family issue.

描述（由申请人提供）：这个小型的 3 年 R01 的目的是测试干预措施的初步效果，以帮助感染 HIV 的母亲向其年幼（6-12 岁）健康的孩子披露其血清状况。这项干预措施的开发基础是两个 R01（MH # 5R01MH057207，目前为 09 年）的工作，旨在纵向评估 HIV 阳性母亲及其子女，其中包括关于母亲披露的研究（例如 Murphy, Marelich, & Hoffman, 2002；Murphy, Marelich, Hoffman, & Schuster, 2006；Murphy, Roberts, & 霍夫曼，2002；墨菲、罗伯茨和霍夫曼，2003 年；墨菲、罗伯茨和霍夫曼，2006 年；墨菲、斯蒂尔斯和戴洛·斯特里托，2001）。这项研究表明，对于感染艾滋病毒的母亲（MLWH）来说，披露信息是很困难的，并且建议的干预措施可以改善母亲和儿童的结果。前两次 R01 中收集的信息将用于制定简短的披露干预措施。 MLWH (N = 80) 将被随机分配到干预或控制条件。 MLWH 和儿童 (N = 160) 将在基线、3、6 和 9 个月的随访时进行评估。干预母亲的随机子集（n = 12）将被要求在最后一次随访后参加深入的定性访谈，以获得有关她们在研究中经历的详细过程信息。干预的目的是：改善母子沟通和养育技能——特别是与披露相关的技能。由于干预目标的缘故，其他主要和次要结果包括：提高披露的准备程度以及披露本身；改善 MLWH 和儿童心理健康指标；减少儿童行为问题，改善亲子关系和家庭功能。这项研究将为 MLWH 对披露其血清状况的调整及其子女对披露的调整提供重要的前瞻性纵向数据。此前的研究表明，对于一些家庭来说，母婴心理困扰可能会在信息披露后立即增加，但随着时间的推移会减少；这项研究的纵向设计将使我们能够在整个披露过程中跟踪母亲和儿童。该研究将允许对母婴特征进行评估，这些特征可能会缓和或调节披露的影响。最后，对每次干预会议的流程评估以及对参加干预的一部分 MLWH 的深入定性访谈将提供有关在全面试验披露干预之前需要解决的问题的信息。除了预防或坚持用药之外，感染艾滋病毒的妇女几乎没有可用的干预措施；这项研究将评估一项干预措施，以帮助艾滋病毒呈阳性的母亲处理严重的家庭问题。