BIOMETRY CORE FACILITY

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biometry Core. [Edsel Pena, Director] This core has been responsible for providing statistical support to the project investigators, including assistance in design of scientific experiments and studies, and the development of appropriate statistical and mathematical models. The Core also works with project faculty and staff in analyzing experimental results and drawing appropriate conclusions in a statistically rigorous manner. This involves (1) giving advice on the proper design of studies in regards to issues of randomization, sample size, and the statistical methods of analyzing the resulting data; (2) developing appropriate methods for determining the appropriate sample sizes to achieve a pre-specified power for a given level of significance that is tailored to the specific situation at hand, which is not covered by existing methods; (3) developing statistical methods of analysis of discrete data (tumor counts) with small sample sizes which is more appropriate for analyzing tumor count data of mice arising from the studies of CCCR personnel; (4) employing survival analytic methods to the analysis of data with which are incomplete or right-censored; (5) developing models and methods of analysis for relating longitudinal markers and event time or recurrent events.