P4: ER TO GOLGI T & VSMC
P4: ER TO GOLGI T & VSMC
批准号:
7610596
负责人:
GUANGYU WU
金额:
$16.09万
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-07-01 至 2008-06-30
关键词:
Blood VesselsComputer Retrieval of Information on Scientific Projects DatabaseEndoplasmic ReticulumFundingGolgi ApparatusGrantInstitutionMolecular ProfilingMuscle CellsNeonatalRattusReceptor SignalingReceptor, Angiotensin, Type 1ResearchResearch PersonnelResourcesRoleSmooth Muscle MyocytesSourceUnited States National Institutes of HealthVentricularbeta-2 Adrenergic Receptorsprotein expressiontrafficking
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The objective of this project is to determine the role of altered ER-to-Golgi trafficking of angiotensin II type 1 receptor (AT1R) and beta 2 adrenergic receptor (AR) in primary cultures of neonatal rat ventricular myocytes and vascular smooth muscle cells. There are three specific aims. First aim is to define the role of Rab1 and other vesicular transport regulators (Sar1, ARF1, Rab2 and Rab6) in the endoplasmic reticulum-to-Golgi transport. Second aim is to determine if alterations in the ER-to-Golgi transport, as a consequence of manipulating Rab1 function, is involved in receptor signaling. Third Aim is to determine the effect of Rab1 on protein expression profile.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
GPCR anterograde trafficking
-
批准号:10592294
-
项目类别:
-
资助金额:$35.42万
-
财政年份:2020
-
负责人:GUANGYU WU
-
依托单位:
GPCR anterograde trafficking
-
批准号:10374034
-
项目类别:
-
资助金额:$35.42万
-
财政年份:2020
-
负责人:GUANGYU WU
-
依托单位:
GPCR anterograde trafficking
-
批准号:10388443
-
项目类别:
-
资助金额:$23.0万
-
财政年份:2020
-
负责人:GUANGYU WU
-
依托单位:
ER-to-Golgi traffic and signal regulation of GPCRs
-
批准号:7924966
-
项目类别:
-
资助金额:$8.24万
-
财政年份:2009
-
负责人:GUANGYU WU
-
依托单位:
ER-to-Golgi traffic and signal regulation of GPCRs
-
批准号:7227755
-
项目类别:
-
资助金额:$24.2万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
COBRE: LSU HSC: P4: ER TO GOLGI T & VSMC
-
批准号:7382066
-
项目类别:
-
资助金额:$20.62万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-cell surface transport and signal regulation of GPCRs
-
批准号:7887450
-
项目类别:
-
资助金额:$28.64万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-Golgi traffic and signal regulation of GPCRs
-
批准号:7615540
-
项目类别:
-
资助金额:$24.2万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-Golgi traffic and signal regulation of GPCRs
-
批准号:7015202
-
项目类别:
-
资助金额:$24.95万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-cell surface transport and signal regulation of GPCRs
-
批准号:8067914
-
项目类别:
-
资助金额:$30.07万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-Golgi traffic and signal regulation of GPCRs
-
批准号:7413736
-
项目类别:
-
资助金额:$24.2万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-cell surface transport and signal regulation of GPCRs
-
批准号:8459462
-
项目类别:
-
资助金额:$29.21万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
ER-to-cell surface transport and signal regulation of GPCRs
-
批准号:8277899
-
项目类别:
-
资助金额:$30.24万
-
财政年份:2006
-
负责人:GUANGYU WU
-
依托单位:
COBRE: LSU HSC: P4: ER TO GOLGI T & VSMC
-
批准号:7171296
-
项目类别:
-
资助金额:$18.52万
-
财政年份:2005
-
负责人:GUANGYU WU
-
依托单位:
COBRE: LSU HSC: ER TO GOLGI T & VSMC
-
批准号:6981962
-
项目类别:
-
资助金额:$19.92万
-
财政年份:2004
-
负责人:GUANGYU WU
-
依托单位: