VALIDATION OF THE CLINICAL DEMENTIA RATING SCALE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 轻度认知障碍（MCI）已被认为是阿尔茨海默病（AD）进展的危险因素。 目前，MCI通常通过临床检查和几种英语工具来识别，这些工具整合了来自可靠旁系来源的信息。 没有这种经过验证的文化适应工具可用于在波多黎各人口中筛查MCI。本研究的目的是文化适应和验证的临床痴呆症评级（CDR）规模，一个基于信息的检查，在波多黎各人口的患者的认知状态的评估。 在文化适应方面，翻译人员将在概念和语言对等、文化背景和口语方面修改阿根廷西班牙语版本的CDR。讲西班牙语的波多黎各人将评估修订后的CDR的清晰度，适当性和文书中使用的语言的文化相关性。为了验证该量表，一名经过认证的CDR评估员将该量表应用于60名被分为三组的个体：正常受试者、无诊断的记忆投诉受试者、诊断为痴呆的受试者及其各自的被调查者。心理学家将测量受试者在几个认知领域的表现。CDR量表的验证将通过测试的灵敏度和特异性以及阳性和阴性预测值来确定，关于记忆主诉患者和AD患者与正常对照的相对地位，通过z评分确定。在本研究中，我们将MCI定义为在一个或多个认知领域中客观记忆障碍低于正常对照至少1.5个标准差（SD）的受试者和在两个或多个认知领域中SD ≥ 2.0的AD患者，将通过受试者操作特征（ROC）曲线来区分MCI受试者、痴呆和正常对照。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mild cognitive impairment (MCI) has been recognized as a risk factor for progression to Alzheimer's disease (AD). Presently, MCI is usually identified by clinical examination and with several instruments in English that integrate information from a reliable collateral source. No such validated culturally adapted instrument is available for the screening of MCI in the Puerto Rican population. The aims of this study are to culturally adapt and validate the Clinical Dementia Rating (CDR) scale, an informant-based examination for the assessment of patient's cognitive status in the Puerto Rican population. For the cultural adaptation, a translator will revise the Argentinean Spanish version of the CDR in terms of conceptual and linguistic equivalence, cultural context, and colloquialisms. Spanish speaking Puerto Ricans will evaluate the revised CDR for clarity, appropriateness, and cultural relevance of the language used in the instrument. To validate the scale, a Certified CDR evaluator will apply the scale to 60 individuals divided into three groups: normal subjects, subjects with memory complaints without a diagnosis, and subjects diagnosed with dementia and their respective informants. A psychologist will measure the subject's performance in several cognitive domains. Validation of the CDR scale will be established by the sensitivity and specificity and the positive and negative predictive values of the test, with respect to the relative standing of patients with memory complaints and with AD from normal controls, determined through z-scores. In this study we define MCI as subjects with an objective memory impairment of at least 1.5 standard deviation (SD) below normal controls in one of more cognitive domain and AD patients with 2.0 SD or more in two or more cognitive domains.Graphic representation will be through receiver operator characteristic (ROC) curves for discrimination between MCI subjects, demented, and normal controls.