THE USE OF MI PASTE FOR SENSITIVITY ASSOCIATED WITH NIGHT-GUARD VITAL BLEACHING

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 漂白或牙齿美白作为一种有效的非侵入性方法来改变因内在或外在染色而变色的牙齿的色度，继续受到欢迎。 用定制托盘漂白是迄今为止牙医最广泛推荐的牙齿美白方法。 牙齿敏感是牙齿外部漂白的常见不良副作用。 MI糊剂最近已被美国牙科协会批准用于治疗过敏症。 MI糊剂中的活性成分是一种乳源性产品，酪蛋白磷酸肽-无定形磷酸钙，通过磷酸钙化合物沉淀到暴露的牙本质表面上导致牙本质小管闭塞来降低敏感性。 也有人主张使用MI糊剂来降低与漂白相关的敏感性。 然而，现有数据基于病例报告，没有良好对照的临床试验研究MI糊剂在接受漂白的患者中的作用。 本研究的目的是评价MI糊剂在有或无超敏反应史的患者中降低与夜间防护活体漂白相关的敏感性的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bleaching or tooth whitening continues to grow in popularity as an effective non-invasive method to alter the shade of teeth discolored by either intrinsic or extrinsic stains. Bleaching with a custom tray is by far the most widely recommended method of tooth whitening by dentists. Tooth sensitivity is a common unpleasant side effect of external tooth bleaching. MI paste has recently been approved by the American Dental Association for the treatment of hypersensitivity. The active ingredient in MI paste is a milk derived product, casein phospho-peptide-amorphous calcium phosphate that reduces sensitivity by precipitation of calcium phosphate compound onto the exposed dentin surface leading to occlusion of dentin tubules. The use of MI paste has also been advocated to reduce the sensitivity associated with bleaching. However, the available data are based on case reports and no well controlled clinical trials have investigated the effect of MI paste in patients undergoing bleaching. The purpose of this study is to evaluate the effectiveness of MI paste in reducing sensitivity associated with night guard vital bleaching in patients with or without a history of hypersensitivity.