SCREENING FOR LUNG CANCER IN THE HIV PATIENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 由于先进的抗逆转录病毒治疗，艾滋病毒患者的寿命延长了。这些患者中的肺癌病例正在增加，死亡率过高。我们决定检查广泛的临床和病理变量，以阐明对生存最关键的风险因素，并确定鉴于艾滋病毒感染的肺癌患者死亡率过高，我们对艾滋病毒阳性患者的纵向临床护理是否需要改变。1989年至2003年，肺癌孢子和艾滋病毒临床数据库产生了87名艾滋病毒阳性肺癌患者。这是此类患者中最大的单一机构队列。我们的长期目标是使用CT扫描来更早地诊断HIV感染患者的肺癌，以便能够开始早期治疗，并可能获得长期生存。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV patients are living longer due to advanced antiretroviral therapy. Cases of lung cancer in these patients are increasing with an excessive mortality rate. We determined to examine a wide range of clinical and pathological variables to elucidate the risk factors most critical to survival, and to determine whether or not our longitudinal clinical care of our HIV-positive patients needed to change given the excessive mortality of HIV-infected patients with lung cancer. The Lung Cancer SPORE and HIV clinic databses have generated 87 HIV-positive lung cancer patients from 1989-2003. This is the largest single institution cohort of such patients. Our long-term goal is to use CT scans to diagnose lung cancer earlier in the HIV-infected patient so that early therapy can be initiated with possible long-term survival.