GENETIC DETERMINANTS OF THE STRESS RESPONSE

应激反应的遗传决定因素

• 批准号: 7604665
• 负责人: SHERITA HILL GOLDEN
• 金额: $ 0.29万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604665
• 关键词: Age; Blood Pressure; Bone Density; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Disease; Fatty acid glycerol esters; Funding; Genetic Determinism; Glucocorticoids; Grant; Health; Hydrocortisone; Hypertension; Institution; Insulin; Lead; Measures; Metabolic syndrome; Organism; Outpatients; Psychological Stress; Recruitment Activity; Research; Research Personnel; Resources; Risk; Source; Stress; System; Trier Social Stress Test; United States National Institutes of Health; Visceral; Woman; biological adaptation to stress; cardiovascular disorder prevention; hypothalamic-pituitary-adrenal axis; insulin sensitivity; men; novel strategies; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While the activation of the hypothalamic-pituitary-adrenal (HPA) axis can be regarded as a basic adaptive mechanism in response to stress, prolonged activation of this system presents a health risk to the organism as highly catabolic glucocorticoids antagonize insulin and increase blood pressure, thus increasing the risk for developing diabetes, hypertension, and arterial disease. Our study has the following specific aims: 1) to recruit 50 men and women ages 18-60 years into an outpatient GCRC study; 2) to measure the cortisol response to the Trier Social Stress Test (TSST); and 3) to examine the relationship between the magnitude of the cortisol responses to psychological stress (TSST) and markers of the metabolic syndrome, including insulin sensitivity, visceral fat and bone density. Understanding the relationship between the stress response and makers of the metabolic syndrome may lead to novel strategies of diabetes and cardiovascular disease prevention.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 虽然下丘脑-垂体-肾上腺（HPA）轴的激活可以被认为是响应于应激的基本适应机制，但是该系统的长期激活对生物体呈现健康风险，因为高度分解代谢的糖皮质激素拮抗胰岛素并增加血压，从而增加发展糖尿病、高血压和动脉疾病的风险。 我们的研究有以下具体目的：1）招募50名年龄在18-60岁的男性和女性参加门诊GCRC研究; 2）测量皮质醇对特里尔社会应激测试（TSST）的反应;和3）检查皮质醇对心理应激反应（TSST）的幅度与代谢综合征标志物（包括胰岛素敏感性）之间的关系，内脏脂肪和骨密度。 了解应激反应和代谢综合征的制造商之间的关系可能会导致糖尿病和心血管疾病预防的新策略。