SHARE

分享

• 批准号: 7604527
• 负责人: Joseph B. Margolick
• 金额: $ 21.99万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604527
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Affect; Anti-Retroviral Agents; Biological; Caucasians; Caucasoid Race; Characteristics; Chicago; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Data; Disease Progression; Effectiveness; Enrollment; Ethnic Origin; Funding; Genetic; Grant; HIV-1; Hepatitis Viruses; Host Defense; Host resistance; Human Herpesvirus 8; Immune response; Individual; Infection; Institution; Laboratories; Los Angeles; Measurement; Monitor; National Institute of Allergy and Infectious Disease; Natural History; Opportunistic Infections; Participant; Pathogenesis; Peripheral Blood Mononuclear Cell; Plasma; Questionnaires; Race; Recruitment Activity; Research; Research Personnel; Resources; Risk Factors; Site; Source; Specimen; T-Lymphocyte Subsets; United States National Institutes of Health; cohort; insight; pathogen; repository; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Study to Help the AIDS Research Effort (SHARE) was funded by NIAID and NCI in 1983 to study the natural history of infection with human immunodeficiency virus, type 1 (HIV). SHARE, along with similar sites in Chicago, Pittsburgh, and Los Angeles, forms the Multicenter AIDS Cohort Study (MACS). MACS participants, including 1447 enrolled in SHARE, have been followed semiannually since 1984 and have provided questionnaire data, physical exam data, laboratory data (including HIV serostatus and T cell subset measurements), and a large repository of plasma, serum, cryopreserved peripheral blood mononuclear cells and other specimens. Evaluating and following the prevalent and incident cases of HIV-infection in SHARE and the MACS, has provided key insights into risk factors for infection with HIV-1, monitoring and mechanisms of progression of HIV infection once it is established, host defense against HIV, genetic factors affecting HIV pathogenesis, and use and efficacy of different therapies for HIV infection and for opportunistic pathogens. SHARE and MACS have just completed the recruitment of 1326 additional participants, including 352 in SHARE, who are younger and more non-caucasian than the cohort previously recruited. Specific Aims include: determine the long-term effectiveness of highly active antiretroviral therarpy (HAART); define determinants of individual responses to HAART including host genetic characteristics, co-infections (hepatitis viruses, HHV-8), immune responses to HIV, adherence, race/ethnicity; define mechanisms of host resistance to HIV infection and progression of the infection; and serve as a platform for independently funded pathogenesis studies and other collaborative research, including virological and immunological mechanisms of HIV-1 pathogenesis, laboratory correlates of disease progression or non-progression, and biological interactions between co-infections and HIV.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 帮助艾滋病研究工作的研究（SHARE）于1983年由NIAID和NCI资助，研究人类免疫缺陷病毒1型（HIV）感染的自然史。 SHARE与芝加哥、匹兹堡和洛杉矶的类似研究中心一起，沿着组成了多中心艾滋病队列研究（MACS）。 自1984年以来，MACS参与者（包括1447名参加SHARE的参与者）每半年进行一次随访，并提供了问卷调查数据、体格检查数据、实验室数据（包括HIV血清状态和T细胞亚群测量）以及大量血浆、血清、冷冻保存的外周血单核细胞和其他标本。 在SHARE和MACS中评估和跟踪HIV感染的流行和偶发病例，为HIV-1感染的风险因素、HIV感染一旦建立后的监测和进展机制、宿主对HIV的防御、影响HIV发病机制的遗传因素以及HIV感染和机会性病原体的不同疗法的使用和疗效提供了关键见解。SHARE和MACS刚刚完成了1326名额外参与者的招募，其中包括SHARE的352名参与者，他们比之前招募的队列更年轻，也更非白人。具体目标包括：确定高效抗逆转录病毒疗法（HAART）的长期有效性;确定HAART个体应答的决定因素，包括宿主遗传特征、合并感染（肝炎病毒，HHV-8），对HIV的免疫应答，依从性，种族/民族;确定宿主对HIV感染和感染进展的抵抗机制;并作为独立资助的发病机制研究和其他合作研究的平台，包括HIV-1发病机制的病毒学和免疫学机制，疾病进展或非进展的实验室相关性，以及共同感染和艾滋病毒之间的生物学相互作用。