FAT REDISTRIBUTION AND METABOLIC CHANGE IN HIV INFECTION: PROTOCOL 2 (FRAM 2)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 框架2是一项由美国国立卫生研究院赞助的研究，有3个目标： 了解感染艾滋病毒的患者是否存在最终可能导致心脏病发作或中风的血管异常 研究脂肪是如何在他们体内分布的，以及 以了解他们的身体是如何处理脂肪和糖的。 参与FRAM 1的HIV感染者被联系，以确定他们是否有资格并对FRAM 2的两次四家访问感兴趣。在这两次访问中，参与者将接受脂肪耐量测试、葡萄糖耐量测试、颈动脉超声、DEXA扫描和MRI。对于这5个程序中的每一个，参与者将获得40美元(最高可达200美元)。此外，这些访问包括基线实验室抽签、体检(目测)、人体测量、自填式问卷和面试者填写的表格。当这两次访问完成后，这些参与者的医疗记录被提取到2000年1月1日，其中包括他们的药物、体重史、T细胞和病毒载量以及病史。 如果患者被认为失去了随访，或死亡或被拒绝，将进行简短的图表审查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. FRAM 2 is an NIH-sponsored study that has 3 goals: to learn whether HIV-infected patients have abnormalities in their blood vessels that could eventually lead to heart attack or stroke to study how fat is distributed in their bodies, and to learn how their bodies handle fat and sugars. HIV-infected individuals who participated in FRAM 1 were contacted to determine if they were eligible and interested in the two four-house visits of FRAM 2. At these two visits, participants would have a Fat Tolerance Test, a Glucose Tolerance Test, a carotid ultrasound, a DEXA scan, and an MRI. For each of these 5 procedures, participants would receive $40 (up to a total of $200). Additionally, these visits include baseline lab draw, physical exam (visual inspection), anthropometry, self-administered questionnaires, and interviewer-administered forms. When these 2 visits had been completed, these participants' medical records are abstracted back to 01 January 2000 for their medications, weight history, T-cell and viral load, and medical history. If patients were deemed lost to follow-up or were deceased or refused, an abbreviated chart review will be conducted.