Antibody-Mediated Autonomic Neuropathy

抗体介导的自主神经病变

• 批准号: 7640796
• 负责人: STEVEN A VERNINO
• 金额: $ 24.86万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640796
• 关键词: Antibodies; Autoimmune Process; Characteristics; Cholinergic Receptors; Chronic; Clinical Research; Disease; Failure; Fc Receptor; Frequencies; Human; Immunoglobulin G; Mediating; Mus; Patients; Phenotype; Physiological; Serological; Syndrome; Tachycardia; autonomic neuropathy

Project 4 will focus on defining autoimmune autonomic neuropathy (AAN) as an antibody-mediated disorder and will evaluate features of antibody-mediated autonomic failure that may be relevant to other dysautonomic syndromes. Studies in this project will provide a direct translational component to the clinical studies of AAN in Project 1 (Dr. Phillip Low) and physiological and serological correlates to the clinical studies of orthostatic tachycardia syndrome (POTS) in Projects 1 and 3 (Dr. Michael Joyner).

项目4将着重于定义自动免疫性神经病（AAN）为抗体介导的疾病，并将 评估可能与其他功能障碍综合症有关的抗体介导的自主衰竭的特征。研究 在该项目中，将为AAN的临床研究提供直接的翻译成分（Phillip Low博士） 项目和血清学与定位性心动过速综合征（POTS）的临床研究相关 1和3（迈克尔·乔伊纳博士）。