CORE--Human Subjects

核心B-摘要 几乎所有现有的对患有精神疾病的女性的妊娠结局研究都遭受了 两个严重缺陷之一：1)依赖回溯性报告，即使主题是前瞻性的 确定，以记录怀孕期间的暴露和病程，以及2)近视焦点在 以最小的努力控制精神疾病的影响的胎儿接触精神药物的影响 疾病/压力，反之亦然。 核心B，即人类学科核心的主要目标是克服这些限制，并提供 该中心的胎儿和婴儿结局项目与一群具有良好特征的婴儿的亲生母亲和父亲一起 怀孕与压力、精神疾病、精神药物和其他 随之而来的暴露包括烟草、非处方药等。 B将前瞻性收集胎儿/婴儿接触母婴精神疾病的纵向指数 疾病和对疾病的治疗将作为独立变量，即暴露在 该中心的临床项目。 人类学科核心的具体目标是：1)扩展我们小组在以下方面的广泛经验 对情绪和焦虑症围产期病程的前瞻性记录 对有和无糖尿病病史孕妇的大样本自然观察性研究 抑郁和/或焦虑症；2)得出每个参与者的准确表型特征 使用一组诊断专用评估工具，3)促进生物样本的获取 将在其他中心核心和项目中进行分析的这一队列，以及4)保持电子 在核心中收集的人口统计、心理测量和生物数据的存储库，可以很容易地 出口用于中心项目的统计分析。

CORE B - Abstract Virtually all existing pregnancy outcome studies for women with psychiatric illness have suffered from one of two critical shortcomings: 1) a reliance on retrospective reports, even when subjects are prospectively identified, to document the exposures and course of illness during gestation, and 2) a myopic focus on the effects of fetal exposure to psychotropic medication with minimal effort to control for the effects of psychiatric illness/stress and vice versa. The principal goal of Core B, the Human Subjects Core, is to overcome these limitations and provide the Center's fetal and infant outcome projects with a cohort of biological mothers and fathers of babies with wellcharacterized pregnancies with respect to stress, psychiatric illness, psychotropic medication, and other concomitant exposures including tobacco, over-the-counter remedies, etc. In summary, the product of Core B will be prospectively collected longitudinal indices of fetal/infant exposure to both maternal psychiatric illness and the treatments for illness that will in turn will serve as the independent, i.e., exposure, variables in the Center's clinical projects. The specific aims of the Human Subjects Core are: 1) to extend our group's extensive experience in prospective documentation of the perinatal course of mood and anxiety disorders by implementing a naturalistic observational study of a large sample of pregnant women with and without a history of depression and/or anxiety disorders; 2) to derive an accurate phenotypic characterization of each participant using a battery of diagnosis specific assessment instruments, 3) to facilitate access to biological samples from this cohort that will be analyzed in other Center cores and projects, and 4) to maintain an electronic repository for the demographic, psychometric, and biological data collected in the Core that can be readily exported for statistical analysis in the Center's projects.