Visceral Adiposity and Mortality in Japanese Americans

日裔美国人的内脏肥胖和死亡率

• 批准号: 7471346
• 负责人: MARGUERITE J MCNEELY
• 金额: $ 12.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7471346
• 关键词: Abdomen; Accounting; Age; Area; Asian Americans; Blood Pressure; Blood Tests; Body fat; Body mass index; Cardiovascular Diseases; Cause of Death; Cessation of life; Cholesterol; Clinical; Communities; Data; Databases; Death Certificates; Diabetes Mellitus; Diagnostic; Diet; Dietary Fats; Dyslipidemias; Enrollment; Family history of; Fasting; Fatty acid glycerol esters; Glucose; Goals; Health; Height; High Density Lipoprotein Cholesterol; Hip region structure; Hypertension; Insulin; Insulin Resistance; Intake; Intra-abdominal; Japan; Japanese American; Japanese Population; Knowledge; LDL Cholesterol Lipoproteins; Lead; Life; Life Style; Lipids; Longitudinal Studies; Measures; Medical History; Metabolic; Metabolic syndrome; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; OGTT; Obesity; Overweight; Pharmaceutical Preparations; Physical activity; Population; Prospective Studies; Public Health; Research; Risk; Smoke; Smoking; Triglycerides; Visceral; Visit; Weight; Woman; X-Ray Computed Tomography; abdominal fat; base; clinically significant; diabetes risk; follow-up; glucose tolerance; improved; indexing; men; mortality; sex

DESCRIPTION (provided by applicant): The Japanese American Community Diabetes Study (JACDS) began in 1983 to describe the metabolic effects of westernization that may contribute to the higher risk for type 2 diabetes observed in Japanese Americans compared with native Japanese and US non-Hispanic whites. This prospective study enrolled a total of 735 men and women of 100% Japanese ancestry. Study visits occurred at baseline, 2.5 years, 5-6 years and 10- 11 years. Complete data for key variables is available for 733 subjects for 1 visit, and 70% of subjects have complete data for 3 visits. At each visit information about medical history, medication use, family history, diet, and physical activity was obtained, and weight, height, blood pressure, fasting blood tests (insulin, glucose and lipids), and visceral (intra-abdominal) fat area by computed tomography were measured. A 75-g oral glucose tolerance test was also performed at each visit. The overall aim of the proposed research is to use this rich longitudinal database to improve knowledge about the clinical significance of excess visceral fat (visceral adiposity). Our specific aim is to determine the associations between visceral adiposity, cardiovascular disease (CVD) mortality and all-cause mortality after accounting for differences in age, sex, smoking, body mass index, diet and physical activity. Mortality and cause of death from death certificates will be ascertained through December 31, 2005 by searching the National Death Index. We project that during the average follow-up period of 18 years there will be 111 deaths from CVD and 250 deaths from all causes among the 733 subjects with complete data for 1 visit. The results of this study will lead to a clearer understanding of the clinical impact of visceral adiposity on cardiovascular disease mortality and all-cause mortality after accounting for commonly used measures of obesity, such as body mass index. PUBLIC HEALTH RELEVANCE: This project is relevant to the public health because it will determine whether excess body fat inside the abdomen (visceral fat) contributes to the risk of death. We will also see whether the risk of death is higher in people who have more visceral fat even after accounting for obesity based on height and weight, diet and physical activity. This study also will improve understanding of the health risks for Asian Americans.

描述（由申请人提供）：日裔美国人社区糖尿病研究（JACDS）始于1983年，旨在描述与日本本土和美国非西班牙裔白人相比，西化可能导致日裔美国人患2型糖尿病风险更高的代谢影响。这项前瞻性研究共招募了735名100%日本血统的男性和女性。研究访问发生在基线、2.5年、5-6年和10- 11年。733名受试者1次访视获得关键变量的完整数据，70%的受试者3次访视获得完整数据。在每次访问时，获得有关病史、药物使用、家族史、饮食和身体活动的信息，并通过计算机断层扫描测量体重、身高、血压、空腹血液检查（胰岛素、葡萄糖和血脂）和内脏（腹腔内）脂肪面积。每次就诊时进行75克口服葡萄糖耐量试验。拟议研究的总体目的是利用这个丰富的纵向数据库来提高对过量内脏脂肪（内脏脂肪）临床意义的认识。我们的具体目的是在考虑到年龄、性别、吸烟、体重指数、饮食和身体活动的差异后，确定内脏肥胖、心血管疾病（CVD）死亡率和全因死亡率之间的关系。截止到2005年12月31日，将通过“全国死亡指数”确认死亡证明书上的死亡人数和死因。我们预计，在平均18年的随访期间，在733名有一次访问完整数据的受试者中，将有111人死于心血管疾病，250人死于各种原因。在考虑了常用的肥胖指标（如体重指数）后，本研究的结果将使人们更清楚地了解内脏脂肪对心血管疾病死亡率和全因死亡率的临床影响。公共卫生相关性：该项目与公共卫生相关，因为它将确定腹部多余的身体脂肪（内脏脂肪）是否会增加死亡风险。我们还将看到，即使将基于身高、体重、饮食和体育活动的肥胖因素考虑在内，内脏脂肪较多的人的死亡风险是否更高。这项研究也将提高对亚裔美国人健康风险的认识。