Molecular attributes and physiological significance of beta1L-adrenoceptors

β1L-肾上腺素受体的分子属性和生理意义

• 批准号: nhmrc : 511216
• 负责人: A/Pr Peter Molenaar
• 金额: $ 50.3万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-attributes-physiological-beta1l-adrenoceptors/82196
• 关键词: Molecular; attributes; physiological; significance; beta1L

Beta-blockers are used for the management of cardiovascular diseases including heart failure. We have discovered that one group of beta-blockers not only blocks the receptor but stimulates it. To explain this we hypothesize that human beta-adrenoceptors exist in two different 'states' , high and low. We are now determining whether 1. the low state causes progression of heart failure, 2. the molecular basis of the two states and 3. we can make new compounds to block the low state.

β-受体阻滞剂用于治疗包括心力衰竭在内的心血管疾病。我们发现一组β受体阻滞剂不仅可以阻断受体，还可以刺激它。为了解释这一点，我们假设人类β-肾上腺素受体存在两种不同的“状态”：高状态和低状态。我们现在正在确定：1.低状态是否会导致心力衰竭的进展，2.这两种状态的分子基础，以及3.我们可以制造新的化合物来阻断低状态。