Molecular attributes and physiological significance of beta1L-adrenoceptors

β-受体阻滞剂用于治疗包括心力衰竭在内的心血管疾病。我们发现，一组β-受体阻滞剂不仅能阻断受体，还能刺激它。为了解释这一点，我们假设人类的β-肾上腺素能受体存在两种不同的“状态”，高和低。我们现在正在确定1.低状态是否会导致心力衰竭的进展，2.这两个状态的分子基础，3.我们可以制造新的化合物来阻断低状态。

Beta-blockers are used for the management of cardiovascular diseases including heart failure. We have discovered that one group of beta-blockers not only blocks the receptor but stimulates it. To explain this we hypothesize that human beta-adrenoceptors exist in two different 'states' , high and low. We are now determining whether 1. the low state causes progression of heart failure, 2. the molecular basis of the two states and 3. we can make new compounds to block the low state.