Childhood Diabetes Clinical & Molecular Research Training Program

描述(由申请人提供)： 儿童糖尿病临床和分子研究培训计划(CDCMRT)的目标是为儿童肥胖、健身和糖尿病方面的学术研究培养博士研究员和医学硕士儿科内分泌学研究员。该计划强调对儿童的2型糖尿病、胰岛素抵抗、肥胖和健康的研究。胰岛素抵抗通常与肥胖有关，并经常导致明显的糖尿病，已成为儿童的主要健康问题。该研究员将有机会在国际公认的实验室开始分子和细胞研究生涯，这些实验室从事胰岛生物学、胰岛素敏感性的生化和分子遗传学研究，或在研究人类代谢、能量消耗、肥胖、健康、高雄激素血症和不同种族人群中的代谢综合征的全身病理生理学方面的职业生涯。目标包括1)建立一个高质量和富有成效的研究项目，2)在受人尊敬的研究期刊上发展一个渐进的发表记录，3)在奖学金期间获得外部资助，以及4)该项目至少50%的毕业生从事儿童糖尿病、胰岛素抵抗和肥胖症研究的学术生涯。为了实现这些目标，与美国国立卫生研究院资助的威斯康星大学临床研究人员预备计划(CIPP)合作开发了一门课程，提供糖尿病和胰岛素抵抗、研究技术、统计学和研究设计、医学伦理、科学写作和演示技能以及拨款申请准备方面的培训。CDCMRT的研究机会包括临床、翻译和基础科学活动，这些活动独立和合作都取得了成功，并针对糖尿病和胰岛素抵抗疾病的研究。这些人口结构和成就，再加上认识到全国缺乏基础科学研究人员和患有儿童期肥胖症和2型糖尿病培训的儿科内分泌学家，促使我们为这个项目寻求资金。威斯康星大学卫生保健多样性研究中心将协助CDCMRT招募代表性不足的少数族裔受训候选人。有了这些机会，CDCMRT计划可以为学员提供全面的指导研究培训体验，为他们在儿童糖尿病、胰岛素抵抗和肥胖症方面的成功研究生涯做好准备。

DESCRIPTION (provided by applicant): The goal of the Childhood Diabetes Clinical & Molecular Research Training Program (CDCMRT) is to train PhD fellows and MD pediatric endocrinology fellows for academic research careers in childhood obesity, fitness and diabetes. The program emphasizes research on type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and often leading to overt diabetes, has become a major health problem in children. The fellow will have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or a career in whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, hyperandrogenemia and the metabolic syndrome in an ethnically diverse population. Objectives include 1) to establish a high quality and productive research project, 2) to develop a progressive record of publication in respected research journals, 3) to obtain extramural grant funding during the fellowship, and 4) to have a minimum of 50% of the graduates of this program pursue an academic career in childhood diabetes, insulin resistance and obesity research. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Clinical Investigator Preparatory Program (CIPP) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. These demographics and accomplishments, together with the recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training have prompted us to seek funding for this program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given these opportunities, the CDCMRT program can provide trainees with a comprehensive mentored research training experience that will prepare them for successful research careers in childhood diabetes, insulin resistance and obesity.