Laboratory Training Program in Radiation Oncology

放射肿瘤学实验室培训计划

• 批准号: 7640735
• 负责人: THEODORE L DEWEESE
• 金额: $ 12.16万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640735
• 关键词: Laboratories; Radiation Oncology; Training Programs

DESCRIPTION (provided by applicant): Radiation therapy is an important tool for the treatment of cancer patients. The evolution and optimization of this multidisciplinary approach to cancer therapy has drawn upon advances in diverse areas of cellular and molecular biology and genetics. Improvements in current treatment regimens will require research-oriented clinicians and basic scientists to explore the effects of radiation on normal and neoplastic tissues and to use new insights to devise strategies for optimizing therapy. Recent advances in these areas have provided not only considerable promise to patients but also opportunities for clinicians and scientists of the future. However, continuing advancement of this field is threatened by a critical shortage of research scientists with expertise in Radiation Oncology. As a major initiative within the newly formed Department of Radiation Oncology and Molecular Radiation Sciences (RO-MRS) at the Johns Hopkins School of Medicine, a specialized Laboratory Training Program has been designed to address this need. The RO-MRS Laboratory Training Program provides young scientists with an intensive laboratory research experience that is supplemented by broad and rigorous coursework. The goal is to impart the knowledge base and skills necessary to engage in cutting edge research, thereby positioning trainees to pursue academic careers. Trainees work in modern, newly constructed laboratories that are directed by renowned investigators who are leaders in basic and translational research. These laboratories house major, funded research programs in areas that include radiation responses of cancer cells, cancer genetics and epigenetics, DNA damage signaling, chromosome maintenance and genetic instability, apoptosis, senescence, DNA repair, novel therapeutic strategies and molecular mechanisms of therapeutic sensitivity - all areas critical to understanding and optimizing radiation therapy. Each trainee works in,an area that is specific to his/her needs and interests. Two types of trainees are supported by this program: 1) Physician scientists (MD or MD/PhD) and 2) Postdoctoral research fellows (PhD or MD/PhD). These junior scientists spend at least two, and preferably three years engaged in full time research in an area of interest directly related to contemporary Radiation Oncology. This application is for the support of two trainees each year.

描述（由申请人提供）：放射治疗是治疗癌症患者的重要工具。这种多学科癌症治疗方法的演变和优化借鉴了细胞和分子生物学以及遗传学不同领域的进步。当前治疗方案的改进将需要以研究为导向的临床医生和基础科学家探索放射对正常和肿瘤组织的影响，并利用新的见解来设计优化治疗的策略。这些领域的最新进展不仅为患者带来了巨大的希望，也为未来的临床医生和科学家提供了机会。然而，该领域的持续发展受到具有放射肿瘤学专业知识的研究科学家严重短缺的威胁。作为约翰霍普金斯大学医学院新成立的放射肿瘤学和分子放射科学系 (RO-MRS) 的一项重大举措，专门的实验室培训计划旨在满足这一需求。 RO-MRS 实验室培训计划为年轻科学家提供密集的实验室研究经验，并辅以广泛而严格的课程作业。目标是传授从事前沿研究所需的知识基础和技能，从而帮助学员从事学术职业。学员在新建的现代化实验室中工作，这些实验室由基础研究和转化研究领域的知名研究人员领导。这些实验室拥有资助的主要研究项目，涉及的领域包括癌细胞的辐射反应、癌症遗传学和表观遗传学、DNA损伤信号传导、染色体维护和遗传不稳定性、细胞凋亡、衰老、DNA修复、新颖的治疗策略和治疗敏感性的分子机制——所有这些领域对于理解和优化放射治疗至关重要。每个学员都在一个特定于他/她的需求和兴趣的领域工作。该计划支持两类学员：1) 医师科学家（MD 或 MD/PhD）和 2) 博士后研究员（PhD 或 MD/PhD）。这些初级科学家至少花费两年，最好是三年的时间，在与当代放射肿瘤学直接相关的感兴趣领域进行全职研究。该申请旨在每年支持两名实习生。