Shared Resources-Clinical Research Services

生物统计学共享资源为YCC的三大主要计划领域提供支持： 临床科学、基础科学和人口科学。提供的服务包括：生物统计 支持研究项目，协助新研究项目的统计和研究工作 和资助申请、数据分析和培训/因此，这一核心对临床试验/研究设计至关重要 过程此外，该核心还主要负责支持方案审查和监测 YCC的过程。因此，该共享资源为以下所有方面提供了关键支持： 统计服务，从研究设计到最终研究报告的撰写。2005年末，西奥多博士 霍尔福德接受了这一核心设施主任的职位。霍尔福德博士将与丹尼尔博士密切合作 Zelterman是生物统计学共享资源的联合主任。生物统计学分享 资源由癌症中心管理，并以表格形式向YCC提供统计支持和数据分析 与六位博士积极磋商致力于YCC的统计学家。两大批评 以前的更新已经解决。具体而言，建立了一个生物统计学临床研究小组， 由Holford博士担任主席，确保生物统计专业知识适用于方案审查委员会 前瞻性临床试验的评价将完全不同于特定研究的评价。 应计数据的设计和后续分析。此外，生物统计工作人员已经大大 扩大，以全面覆盖由制药商发起的临床研究的显著增加 这是由于招募了大量新的临床研究人员。在过去2 多年来，11名新的研究性临床肿瘤学家加入了YCC，他们的临床试验工作导致了 所需的生物统计支持增加了56%。为了满足这些日益增长的需求， 该共享资源的生物统计学教师从2人增加到7人。在此更新申请中，我们 要求为下一个资助期提供1.75 FTE。 在2005年，100%，或42，用户是YCC成员（65.5%同行评审），来自所有8个YCC研究 程序

The Biostatistics Shared Resource provides support for the three broad major programmatic areas of YCC: clinical science; basic science; and population science. The services provided include: biostatistical support to research projects, assistance with the statistical and research aspects of new research projects and grant applications, data analysis, and training/As such, this core is vital to clinical trials/study design process. Additionally, this core has the major responsibility to support the protocol review and monitoring process of the YCC. Thus, this Shared Resource provides critical support for the complete spectrum of statistical services, from study design through the final research report writing. In late 2005, Dr. Theodore Holford accepted the position as Director of this core facility. Dr. Holford will work closely with Dr. Daniel Zelterman, who serves as Co-Director of the Biostatistics Shared Resource. The Biostatistics Shared Resource is Cancer Center Managed and provides statistical support and data analysis to YCC in the form of active consultation with six Ph.D. statisticians dedicated to the YCC. The 2 major criticisms of the previous renewal have been addressed. Specifically, creation of a Biostatistics Clinical Studies Group, chaired by Dr. Holford, ensures that biostatistical expertise applied to Protocol Review Committee evaluation of prospective clinical trials will be completely distinct from that involved in the particular study's design and subsequent analysis of accrued data. In addition, the biostatistical staff has been significantly expanded, to provide full coverage for the marked increase in investigator-initiated clinical research activities, resulting from the recruitment of a large number of new clinical researchers. Over the past 2 years, 11 new investigative clinical oncologists have joined the YCC, and their clinical trials efforts have led to a 56% increase in the required biostatistical support. In order to support these increased needs, the faculty biostatistician staff of this Shared Resource has grown from 2 to 7. In this renewal application, we are requesting 1.75 FTE for the next period of funding. In 2005 100%, or 42, users were YCC members (65.5% Peer reviewed) from all 8 of the YCC research programs