Molecular characterisation of host cell targets of human pathogenic viruses and evaluating their potential as novel therapeutic targets.

人类病原病毒宿主细胞靶标的分子特征并评估其作为新治疗靶点的潜力。

• 批准号: nhmrc : 1037092
• 负责人: Dr Mohamad Aljofan
• 金额: $ 20.53万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-characterisation-host-therapeutic-targets/111046
• 关键词: Molecular; characterisation; host; cell; targets

There are currently no therapeutics to treat victims of Hendra, Nipah or Rabies virus infections, which account for > 50,000 deaths/yr worldwide. Through not fully understood mechanisms, these viruses affect the functions of specific cellular proteins in order to inhibit the host immune system, a process essential to their pathogenicity. We aim to characterise the mechanisms underlying viral inhibition of host immunity and evaluate their potential as novel targets to develop urgently needed therapeutics against these deadly pathogens.

目前还没有治疗亨德拉、尼帕或狂犬病病毒感染的药物，这些病毒每年在全球造成5万人死亡。通过不完全理解的机制，这些病毒影响特定细胞蛋白质的功能，以抑制宿主免疫系统，这是其致病性所必需的过程。我们的目标是阐明病毒抑制宿主免疫的机制，并评估它们作为新靶点的潜力，以开发针对这些致命病原体的迫切需要的治疗方法。